Deficits in the activation of human oculomotor nuclei in chronic traumatic brain injury

Tyler, C. W., Likova, L. T., Mineff, K. N. & Nicholas, S. C. (2015). Deficits in the activation of human oculomotor nuclei in chronic traumatic brain injury. Frontiers in Neurology, 6, p. 173. doi: 10.3389/fneur.2015.00173

[img]
Preview
Text - Published Version
Available under License Creative Commons: Attribution International Public License 4.0.

Download (10MB) | Preview

Abstract

Binocular eye movements form a finely tuned system that requires accurate coordination of the oculomotor dynamics of the brainstem control nuclei when tracking the fine binocular disparities required for 3D vision. They are particularly susceptible to disruption by brain injury and other neural dysfunctions. Here, we report functional magnetic resonance imaging activation of the brainstem oculomotor control nuclei by binocular saccadic and vergence eye movements, and significant reductions in their response amplitudes in mild or diffuse traumatic brain injury (dTBI). Bilateral signals were recorded from a non-TBI control group (n = 11) in the oculomotor control system of the superior colliculi, the oculomotor nuclei, the abducens nuclei, and in the supra-oculomotor area (SOA), which mediate vergence eye movements. Signals from these nuclei were significantly reduced overall in a dTBI group (n = 12) and in particular for the SOA for vergence movements, which also showed significant decreases in velocity for both the convergence and divergence directions.

Item Type: Article
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RE Ophthalmology
Divisions: School of Health Sciences > Department of Optometry & Visual Science
URI: http://openaccess.city.ac.uk/id/eprint/12519

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics