Penetration of high intensity focused ultrasound in vitro and in vivo rabbit brain using MR imaging

Hadjisavvas, V., Damianou, C., Ioannides, K., Mylonas, N., Couppis, A., Kyriacou, P. A., Iosif, D., HadjiCharalambous, T. & Parea, G. (2009). Penetration of high intensity focused ultrasound in vitro and in vivo rabbit brain using MR imaging. Paper presented at the 2009 9th International Conference on Information Technology and Applications in Biomedicine, 4-7 Nov 2009, Larnaca, Cyprus.

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In this paper magnetic resonance imaging (MRI) is investigated for monitoring the penetration of high intensity focused ultrasound (HIFU) ex vivo and in vivo rabbit brain. A single element spherically focused transducer of 5 cm diameter, focusing at 10 cm and operating at 2 MHz was used. A prototype MRI- compatible positioning device is described. MRI images were taken using fast spin echo (FSE). The length of the lesions in vivo rabbit brain was much higher than the length ex vivo, proving that the penetration in the ex vivo brain is limited by reflection due to trapped bubbles in the blood vessels.

Item Type: Conference or Workshop Item (Paper)
Additional Information: © 2009 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
Subjects: R Medicine > RA Public aspects of medicine
T Technology > TK Electrical engineering. Electronics Nuclear engineering
Divisions: School of Engineering & Mathematical Sciences > Engineering

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