A prospective, randomised, double-blind, double-dummy, placebo-controlled trial to assess the respiratory effects of buprenorphine versus morphine in anaesthetised patients

Nikolic, S., Mehta, V., Ratcliffe, S., Phillips, J. P., Kyriacou, P. A. & Langford, R. M. (2008). A prospective, randomised, double-blind, double-dummy, placebo-controlled trial to assess the respiratory effects of buprenorphine versus morphine in anaesthetised patients. Paper presented at the The 14th World Congress of Anaesthesiologists, 2-7 Mar 2008, Cape Town, South Africa.

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Abstract

Despite its long history and widespread use, some questions remain over buprenorphine’s respiratory safety profile. This study investigated respiratory depression and potential reversibility by naloxone at two buprenorphine doses, of which the intramuscularly administered dose was designed to achieve the plasma concentration range seen with transdermal delivery. The buprenorphine doses were compared to morphine administered intravenously.

The IM route was proposed to avoid the characteristic high peak seen after IV bolus injection, to achieve a slow-rising plasma concentration which plateaus at five minutes, The selected intramuscular buprenorphine dose (0.85 mcg/kg) was chosen to achieve a similar plasma concentration at a steady state to that seen with transdermal buprenorphine at 35mcg/h(the Transtec 35mcg/h patch).

Item Type: Conference or Workshop Item (Paper)
Subjects: R Medicine > R Medicine (General)
T Technology > TA Engineering (General). Civil engineering (General)
Divisions: School of Engineering & Mathematical Sciences > Engineering
URI: http://openaccess.city.ac.uk/id/eprint/14296

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