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Automating the processing of cDNA microarray images

Liatsis, P., Nazarboland, M. A., Goulermas, J. Y., Zeng, X. J. and Milonidis, E. (2008). Automating the processing of cDNA microarray images. International Journal of Intelligent Systems Technologies and Applications, 5(1-2), pp. 115-144. doi: 10.1504/IJISTA.2008.01817

Abstract

This work is concerned with the development of an automatic image processing tool for DNA microarray images. This paper proposes, implements and tests a new tool for cDNA image analysis. The DNAs are imaged as thousands of circularly shaped objects (spots) on the microarray image and the purpose of this tool is to correctly address their location, segment the pixels belonging to spots and extract the quality features of each spot. Techniques used for addressing, segmentation and feature extraction of spots are described in detail. The results obtained with the proposed tool are systematically compared with conventional cDNA microarray analysis software tools.

Publication Type: Article
Publisher Keywords: addressing; cDNA microarrays; feature extraction; gene expression levels; segmentation; spot detection; DNA microarrays; microarray images; image processing
Subjects: Q Science > QH Natural history > QH426 Genetics
T Technology > TK Electrical engineering. Electronics Nuclear engineering
Departments: School of Mathematics, Computer Science & Engineering > Engineering
School of Mathematics, Computer Science & Engineering > Engineering > Electrical & Electronic Engineering
URI: http://openaccess.city.ac.uk/id/eprint/14869
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