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Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells

Cohen, N. R., Brennan, P. J., Shay, T., Watts, G. F., Brigl, M., Kang, J., Brenner, M. B. and ImmGen Project Consortium, . (2013). Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells. Nature Immunology, 14(1), pp. 90-99. doi: 10.1038/ni.2490

Abstract

Invariant natural killer T cells (iNKT cells) are innate-like T lymphocytes that act as critical regulators of the immune response. To better characterize this population, we profiled gene expression in iNKT cells during ontogeny and in peripheral subsets as part of the Immunological Genome Project. High-resolution comparative transcriptional analyses defined developmental and subset-specific programs of gene expression by iNKT cells. In addition, we found that iNKT cells shared an extensive transcriptional program with NK cells, similar in magnitude to that shared with major histocompatibility complex (MHC)-restricted T cells. Notably, the program shared by NK cells and iNKT cells also operated constitutively in γδ T cells and in adaptive T cells after activation. Together our findings highlight a core effector program regulated distinctly in innate and adaptive lymphocytes.

Publication Type: Article
Additional Information: Published by Nature Publishing Group, 2013
Subjects: Q Science > QA Mathematics > QA75 Electronic computers. Computer science
Q Science > QR Microbiology > QR180 Immunology
Departments: School of Mathematics, Computer Science & Engineering > Computer Science
URI: http://openaccess.city.ac.uk/id/eprint/15377
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