Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells

Cohen, N. R., Brennan, P. J., Shay, T., Watts, G. F., Brigl, M., Kang, J., Brenner, M. B. & ImmGen Project Consortium, . (2013). Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells. Nature Immunology, 14(1), pp. 90-99. doi: 10.1038/ni.2490

[img]
Preview
Text - Accepted Version
Download (2MB) | Preview

Abstract

Invariant natural killer T cells (iNKT cells) are innate-like T lymphocytes that act as critical regulators of the immune response. To better characterize this population, we profiled gene expression in iNKT cells during ontogeny and in peripheral subsets as part of the Immunological Genome Project. High-resolution comparative transcriptional analyses defined developmental and subset-specific programs of gene expression by iNKT cells. In addition, we found that iNKT cells shared an extensive transcriptional program with NK cells, similar in magnitude to that shared with major histocompatibility complex (MHC)-restricted T cells. Notably, the program shared by NK cells and iNKT cells also operated constitutively in γδ T cells and in adaptive T cells after activation. Together our findings highlight a core effector program regulated distinctly in innate and adaptive lymphocytes.

Item Type: Article
Additional Information: Published by Nature Publishing Group, 2013
Subjects: Q Science > QA Mathematics > QA75 Electronic computers. Computer science
Q Science > QR Microbiology > QR180 Immunology
Divisions: School of Informatics > Department of Computing
URI: http://openaccess.city.ac.uk/id/eprint/15377

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics