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Working Memory Load Modulates Neuronal Coupling

Pinotsis, D. A. ORCID: 0000-0002-6865-8103, Buschman, T. J. and Miller, EK (2018). Working Memory Load Modulates Neuronal Coupling. Cerebral Cortex, doi: 10.1093/cercor/bhy065

Abstract

There is a severe limitation in the number of items that can be held in working memory. However, the neurophysiological limits remain unknown. We asked whether the capacity limit might be explained by differences in neuronal coupling. We developed a theoretical model based on Predictive Coding and used it to analyze Cross Spectral Density data from the prefrontal cortex (PFC), frontal eye fields (FEF), and lateral intraparietal area (LIP). Monkeys performed a change detection task. The number of objects that had to be remembered (memory load) was varied (1–3 objects in the same visual hemifield). Changes in memory load changed the connectivity in the PFC–FEF–LIP network. Feedback (top-down) coupling broke down when the number of objects exceeded cognitive capacity. Thus, impaired behavioral performance coincided with a break-down of Prediction signals. This provides new insights into the neuronal underpinnings of cognitive capacity and how coupling in a distributed working memory network is affected by memory load.

Publication Type: Article
Additional Information: This is a pre-copyedited, author-produced version of an article accepted for publication in Cerebral Cortex following peer review. The version of record Dimitris A Pinotsis, Timothy J Buschman, Earl K Miller; Working Memory Load Modulates Neuronal Coupling, Cerebral Cortex is available online at: https://doi.org/10.1093/cercor/bhy065.
Departments: School of Arts & Social Sciences > Psychology
URI: http://openaccess.city.ac.uk/id/eprint/19418
[img] Text - Accepted Version
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