City Research Online

Multimodal Brain Changes in First-Episode Mania: A Voxel-Based Morphometry, Functional Magnetic Resonance Imaging, and Connectivity Study

Goikolea, J. M., Dima, D. ORCID: 0000-0002-2598-0952, Landín-Romero, R., Torres, I., Delvecchio, G., Valenti, M., Amann, B., Bonnin, C. M., McKenna, P. J., Pomarol-Clotet, E., Frangou, S. and Vieta, E. (2018). Multimodal Brain Changes in First-Episode Mania: A Voxel-Based Morphometry, Functional Magnetic Resonance Imaging, and Connectivity Study. Schizophrenia Bulletin, doi: 10.1093/schbul/sby047

Abstract

Background: Brain structural and functional changes in bipolar disorder (BD) are well-established findings, but it is uncertain whether these changes are already present in first episode mania (FEM).

Methods: We compared 31 FEM subjects, with 31 healthy individuals matched for age, sex, and premorbid IQ. Whole-brain voxel-wise morphometry, functional magnetic resonance imaging during the n-back task, and a functional connectivity analysis were performed.

Results: There were no volumetric differences between the 2 groups. During the 2-back task, FEM patients did not perform differently from controls and activated similar regions, but they showed less deactivation in the ventromedial prefrontal cortex (vmPFC), the anterior hub of the default mode network (DMN). They showed preserved functional connectivity between the vmPFC and other regions of the DMN, but increased connectivity with the superior frontal gyrus.

Conclusions: The absence of volumetric changes in FEM patients suggests that these changes could be related to progression of the illness. On the other hand, the failure of deactivation of the anterior hub of the DMN is present from the onset of the illness and may represent a core pathophysiological feature of BD.

Publication Type: Article
Additional Information: This is a pre-copyedited, author-produced version of an article accepted for publication in Schizophrenia Bulletin following peer review. The version of record Goikolea, J. M., Dima, D., Landín-Romero, R., Torres, I., Delvecchio, G., Valenti, M., Amann, B., Bonnin, C. M., McKenna, P. J., Pomarol-Clotet, E., Frangou, S. & Vieta, E. (2018). Multimodal Brain Changes in First-Episode Mania: A Voxel-Based Morphometry, Functional Magnetic Resonance Imaging, and Connectivity Study. Schizophrenia Bulletin, is available online at: https://doi.org/10.1093/schbul/sby047
Publisher Keywords: neuroimaging, bipolar disorder, pathophysiology, mania, magnetic resonance imaging, whole-brain statistical analysis
Departments: School of Arts & Social Sciences > Psychology
URI: http://openaccess.city.ac.uk/id/eprint/19546
[img] Text - Accepted Version
This document is not freely accessible until 17 April 2019 due to copyright restrictions.

To request a copy, please use the button below.

Request a copy

Export

Downloads

Downloads per month over past year

View more statistics

Actions (login required)

Admin Login Admin Login