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Optimization of Tetrapolar Impedance Electrodes in Microfluidic Devices for Point of Care Diagnostics using Finite Element Modeling

Hantschke, M., Sideris, D., Kyriacou, P. A. ORCID: 0000-0002-2868-485X and Triantis, I. ORCID: 0000-0002-8900-781X (2018). Optimization of Tetrapolar Impedance Electrodes in Microfluidic Devices for Point of Care Diagnostics using Finite Element Modeling. Paper presented at the 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 18-21 Jul 2018, Honolulu, USA.

Abstract

Electrophoresis is widely applied in the field of biochemistry and molecular biology. Tetrapolar electrical impedance sensing (TEIS) has been shown capable of replacing the conventional detection technology in order to develop a point of care electrophoretic analyzer. Besides the advantages of reduced influence of electrode polarization, TEIS is affected by sensitivity distribution depending on the electrode design. A well reported practice outside of electrophoresis, systematic investigation of the effects of sensitivity distribution on the TEIS in microfluidic devices has not been conducted. Here we utilize finite element modeling, backed by experimental results, to optimize the sensor design within an electrophoretic separation device. Numerous sensor designs were validated regarding detectability, sensitivity and spatial resolution. The results show, that minimizing the distance between the central/pick-up electrodes increases sensitivity and spatial resolution whereas the distance between the central electrodes and the outer electrode do not influence sensitivity and spatial resolution.

Publication Type: Conference or Workshop Item (Paper)
Additional Information: © 2018 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
Subjects: T Technology > TK Electrical engineering. Electronics Nuclear engineering
Departments: School of Mathematics, Computer Science & Engineering > Engineering > Electrical & Electronic Engineering
URI: http://openaccess.city.ac.uk/id/eprint/21887
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