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Insight, cognition and quality of life in Alzheimer's disease

Hurt, C. S., Banerjee, S., Tunnard, C., Whitehead, D. L., Tsolaki, M., Mecocci, P., Kloszewska, I., Soininen, H., Vellas, B. and Lovestone, S. (2010). Insight, cognition and quality of life in Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry, 81(3), pp. 331-336. doi: 10.1136/jnnp.2009.184598

Abstract

Background: The detrimental impact of dementia upon patient health-related quality of life (HRQL) is well established, as is the importance of improving HRQL. However, relatively little is known about the natural history of HRQL in dementia and those factors influencing it. This limited knowledge potentially restricts the evaluation of the efficacy of interventions designed to improve HRQL. One such area concerns the relationship between HRQL and patient insight. It remains unclear what impact, if any, impaired insight has upon a patient's HRQL. The present study aimed to investigate the relationship between insight and HRQL in a sample of patients with Alzheimer's disease (AD) and their carers.

Methods: 256 patients with AD were recruited as part of AddNeuroMed, a multicentre European AD biomarkers study. Of these, 174 completed a quality-of-life measure in addition to a comprehensive battery of clinical and neuropsychological assessments.

Results: Insight was found to be differentially related to patient perceptions of HRQL in mild and moderate dementia. Within moderate dementia, impaired insight was associated with better perceived HRQL. Conversely, cognition, but not insight, was associated with impaired HRQL in mild dementia. Insight was not found to be associated with carer perceptions of patient HRQL.

Conclusion: Impairment of insight is associated with better HRQL in moderate dementia. This finding has implications for interventions which focus on increasing patient awareness and orientation, as impairment of insight appears to have a positive impact upon HRQL.

Publication Type: Article
Publisher Keywords: Activities of Daily Living, Aged, Aged, 80 and over, Alzheimer Disease, Anxiety Disorders, Awareness, Caregivers, Cognition Disorders, Cost of Illness, Depressive Disorder, Female, Humans, Male, Mental Disorders, Mental Status Schedule, Middle Aged, Neuropsychological Tests, Quality of Life
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Departments: School of Health Sciences > Healthcare Services Research & Management
URI: http://openaccess.city.ac.uk/id/eprint/3289
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Official URL: http://jnnp.bmj.com/

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