Design and synthesis of a fluorescent molecular imprinted polymer for use in an optical fibre-based cocaine sensor

Wren, S., Piletsky, S, Karim, K., Gascoine, P., Lacey, R., Sun, T. & Grattan, K. T. V. (2014). Design and synthesis of a fluorescent molecular imprinted polymer for use in an optical fibre-based cocaine sensor. Proceedings of SPIE - The International Society for Optical Engineering, 9157, 91574W. doi: 10.1117/12.2059278

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Abstract

Previously, we have developed chemical sensors using fibre optic-based techniques for the detection of Cocaine, utilising molecularly imprinted polymers (MIPs) containing fluorescein moieties as the signalling groups. Here, we report the computational design of a fluorophore which was incorporated into a MIP for the generation of a novel sensor that offers improved sensitivity for Cocaine with a detection range of 1-100 micro-grams. High selectivity for Cocaine over a suite of known Cocaine interferants (25 micro-grams) was also demonstrated by measuring changes in the intensity of fluorescence signals received from the sensor.

Item Type: Article
Additional Information: Copyright 2014 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
Uncontrolled Keywords: Optical fibre sensor, Cocaine sensor, chemical sensor, molecular imprinting, computational design
Subjects: T Technology > TA Engineering (General). Civil engineering (General)
Divisions: School of Engineering & Mathematical Sciences > Engineering
URI: http://openaccess.city.ac.uk/id/eprint/4576

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