Estimation of apparent tumor vascular permeability from multiphoton fluorescence microscopic images of P22 rat sarcomas in vivo

Reyes-Aldasoro, C. C., Wilson, I., Prise, V. E., Barber, P. R., Ameer-Beg, M., Vojnovic, B., Cunningham, V. J. & Tozer, G. M. (2008). Estimation of apparent tumor vascular permeability from multiphoton fluorescence microscopic images of P22 rat sarcomas in vivo. Microcirculation, 15(1), pp. 65-79. doi: 10.1080/10739680701436350

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Abstract

To develop an image processing-based method to quantify the rate of extravasation of fluorescent contrast agents from tumor microvessels, and to investigate the effect of the tumor vascular disrupting agent combretastatin A-4-P (CA-4-P) on apparent tumor vascular permeability to 40 kDa fluorescein isothiocyanate (FITC) labeled dextran.

Item Type: Article
Additional Information: This is the accepted version of the following article: Reyes-Aldasoro, C. C., Wilson, I., Prise, V. E., Barber, P. R., Ameer-Beg, M., Vojnovic, B., Cunningham, V. J. and Tozer, G. M. (2008), Estimation of Apparent Tumor Vascular Permeability from Multiphoton Fluorescence Microscopic Images of P22 Rat Sarcomas In Vivo. Microcirculation, 15: 65–79., which has been published in final form at http://dx.doi.org/10.1080/10739680701436350
Uncontrolled Keywords: combretastatin; multiphoton fluorescence microscopy; segmentation; tumor vascular disrupting agents; vascular permeability
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
T Technology > T Technology (General)
Divisions: School of Engineering & Mathematical Sciences > Engineering
Related URLs:
URI: http://openaccess.city.ac.uk/id/eprint/5510

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