The anterior temporal lobe semantic hub is a part of the language neural network: selective disruption of irregular past tense verbs by rTMS

Holland, R. & Lambon Ralph, M. A. (2010). The anterior temporal lobe semantic hub is a part of the language neural network: selective disruption of irregular past tense verbs by rTMS. Cerebral Cortex, 20(12), pp. 2771-2775. doi: 10.1093/cercor/bhq020

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Abstract

There is growing evidence from patient and neuroimaging studies that the anterior temporal lobe (ATL) should be considered a crucial part of the neural network that underpins language. Specifically, this region supports semantic representations that play a key role in various aspects of language processing. In this study, we tested the critical importance of this region for language processing in normal participants by applying repetitive transcranial magnetic stimulation over the left ATL semantic region. The ability to generate the past tense of English verbs has often been used as a test case for neurocognitive models of language. Accordingly, we used this aspect of language to investigate the impact of repetitive transcranial magnetic stimulation (rTMS) over the left ATL. As predicted by single mechanism accounts of past-tense generation, ATL rTMS had a selective impact on participants' ability to generate the past tense of irregular verbs. When combined with other evidence, these results confirm that the ATL semantic hub is a key component of the neural network for language.

Item Type: Article
Additional Information: This is a pre-copyedited, author-produced PDF of an article accepted for publication in Cerebral Cortex following peer review. The version of record Holland, R & Lambon Ralph, MA (0012). The anterior temporal lobe semantic hub is a part of the language neural network: selective disruption of irregular past tense verbs by rTMS.. Cereb Cortex, 20(12), pp. 2771-2775 is available online at: http://dx.doi.org/10.1093/cercor/bhq020
Uncontrolled Keywords: anterior temporal lobe, language, semantic memory, TMS
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: School of Health Sciences > Department of Language & Communication Science
URI: http://openaccess.city.ac.uk/id/eprint/7385

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