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Exploring intermediate phenotypes with EEG: Working memory dysfunction in schizophrenia

Haenschel, C. & Linden, D. (2011). Exploring intermediate phenotypes with EEG: Working memory dysfunction in schizophrenia. Behavioural Brain Research, 216(2), pp. 481-495. doi: 10.1016/j.bbr.2010.08.045


This review brings together two strands of investigation in the neuropsychology and neurophysiology of schizophrenia that have been particularly productive over the last 20 years. We review the literature on working memory deficits, particularly in the visual domain, and changes in oscillatory neural activity as measured with electroencephalography (EEG) and magnetoencephalography (MEG). We argue that recent results suggest a link between these two phenomena, in that altered oscillations underlie some of the working memory deficits. We furthermore argue that early sensory mechanisms contribute more to working memory (and other) deficits than previously thought. The final part of our review suggests links between working memory, oscillations, and their alterations in schizophrenia and the dopamine, GABA, glutamate and acetylcholine system. These links have already resulted in the development of new remediation strategies, which have some translational potential.

Publication Type: Article
Additional Information: © 2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Publisher Keywords: Working Memory; Encoding; Schizophrenia; EEG; Oscillations; Synchrony; Neuropharmacology
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Departments: School of Health & Psychological Sciences > Psychology
SWORD Depositor:
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