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Analysis of Neural-BOLD Coupling Through Four Models of the Neural Metabolic Demand

Tyler, C. W., Likova, L.T. & Nicholas, S. C. (2015). Analysis of Neural-BOLD Coupling Through Four Models of the Neural Metabolic Demand. Frontiers in Neuroscience, 9, 419. doi: 10.3389/fnins.2015.00419


The coupling of the neuronal energetics to the blood-oxygen-level-dependent (BOLD) response is still incompletely understood. To address this issue, we compared the fits of four plausible models of neurometabolic coupling dynamics to available data for simultaneous recordings of the local field potential and the local BOLD response recorded from monkey primary visual cortex over a wide range of stimulus durations. The four models of the metabolic demand driving the BOLD response were: direct coupling with the overall LFP; rectified coupling to the LFP; coupling with a slow adaptive component of the implied neural population response; and coupling with the non-adaptive intracellular input signal defined by the stimulus time course. Taking all stimulus durations into account, the results imply that the BOLD response is most closely coupled with metabolic demand derived from the intracellular input waveform, without significant influence from the adaptive transients and nonlinearities exhibited by the LFP waveform.

Publication Type: Article
Publisher Keywords: fMRI, metabolic coupling, neural signal estimation, human brain, multimodal imaging, BOLD, local field potentials
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Departments: School of Health & Psychological Sciences > Optometry & Visual Sciences
Text - Published Version
Available under License Creative Commons: Attribution International Public License 4.0.

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