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Photoplethysmographic measurements from central nervous system tissue

Phillips, J. P., Kyriacou, P. A., Chang, S. H. , Maney, K., George, K. & Langford, R. M. (2007). Photoplethysmographic measurements from central nervous system tissue. Journal of Physics: Conference Series, 85(1), article number 12029. doi: 10.1088/1742-6596/85/1/012029


A new system for measuring the oxygen saturation of blood within tissue has been developed, for a number of potential patient monitoring applications. This proof of concept project aims to address the unmet need of real-time measurement of oxygen saturation in the central nervous system (CNS) for patients recovering from neurosurgery or trauma, by developing a fibre optic signal acquisition system for internal placement through small apertures. The development and testing of a two-wavelength optical fibre reflectance photoplethysmography (PPG) system is described together with measurements in rats and preliminary results from a clinical trial of the system in patients undergoing neurosurgery. It was found that good quality red and near-infrared PPG signals could be consistently obtained from the rat spinal cord (n=6) and human cerebral cortex (n=4) using the fibre optic probe. These findings justify further development and clinical evaluation of this fibre optic system.

Publication Type: Article
Subjects: R Medicine > RC Internal medicine
T Technology > TK Electrical engineering. Electronics Nuclear engineering
Departments: School of Science & Technology > Engineering
[thumbnail of Justin ICOLAD paper 2501 DRAFT.pdf]
Text - Accepted Version
Available under License Creative Commons: Attribution 3.0.

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