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A guide to medication adherence in depression

Mutsatsa, S. (2016). A guide to medication adherence in depression. British Journal of Mental Health Nursing, 5(6), pp. 259-261. doi: 10.12968/bjmh.2016.5.6.259


Depression is a common mental health disorder that affects at least 350 million people worldwide and exerts a negative effect upon a person’s physical, mental and social functions, and it is associated with an increased risk of premature death. The treatment of depression involves the use of antidepressants and selective serotonin inhibitors are currently the first line of treatment. In particular, fluoxetine is safe and effective in the treatment the disorder. It is one of the few antidepressants licensed for use in children under the age of 18 years in the UK. Fluoxetine is associated with fewer dose adjustments compared to other SSRIs and this simplifies therapy and may improve outcomes. However, fluoxetine induces a number of side effects like, nausea, insomnia, sexual dysfunction and its interaction with monoamine oxidase inhibitors can cause the serotonin syndrome.

Publication Type: Article
Additional Information: This document is the Accepted Manuscript version of a Published Work that appeared in final form in British Journal of Mental Health Nursing, copyright © MA Healthcare, after peer review and technical editing by the publisher. To access the final edited and published work see
Departments: School of Health & Psychological Sciences
Text - Accepted Version
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