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Classification of Major Depressive Disorder via Multi-Site Weighted LASSO Model

Zhu, D., Riedel, B. C., Jahanshad, N. , Groenewold, N. A., Stein, D.J., Gotlib, I. H., Sacchet, M. D., Dima, D., Cole, J. H., Fu, C. H. Y., Walter, H., Veer, I. M., Frodl, T., Schmaal, L., Veltman, D.J. & Thompson, P.M. (2017). Classification of Major Depressive Disorder via Multi-Site Weighted LASSO Model. Paper presented at the 20th International Conference on Medical Image Computing and Computer Assisted Intervention, 10-14 Sep 2017, Quebec City, Canada.


Large-scale collaborative analysis of brain imaging data, in psychiatry and neurology, offers a new source of statistical power to discover features that boost accuracy in disease classification, differential diagnosis, and outcome prediction. However, due to data privacy regulations or limited accessibility to large datasets across the world, it is challenging to efficiently integrate distributed information. Here we propose a novel classification framework through multi-site weighted LASSO: each site performs an iterative weighted LASSO for feature selection separately. Within each iteration, the classification result and the selected features are collected to update the weighting parameters for each feature. This new weight is used to guide the LASSO process at the next iteration. Only the features that help to improve the classification accuracy are preserved. In tests on data from five sites (299 patients with major depressive disorder (MDD) and 258 normal controls), our method boosted classification accuracy for MDD by 4.9% on average. This result shows the potential of the proposed new strategy as an effective and practical collaborative platform for machine learning on large scale distributed imaging and biobank data.

Publication Type: Conference or Workshop Item (Paper)
Additional Information: Published in Lecture Notes in Computer Science. The final authenticated version is available online at Springer at
Publisher Keywords: MDD, weighted LASSO
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Departments: School of Arts & Social Sciences > Psychology
Text - Accepted Version
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