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Comparison of Interactions Between Control and Mutant Macrophages

Solí­s-Lemus, J., Sánchez-Sánchez, B. J., Marcotti, S., Burki, M., Stramer, B. and Reyes-Aldasoro, C. C. ORCID: 0000-0002-9466-2018 (2020). Comparison of Interactions Between Control and Mutant Macrophages. In: Zheng, Y., Williams, B. M. and Chen, K. (Eds.), Medical Image Understanding and Analysis (MIUA 2019). (pp. 470-477). Cham, Switzerland: Springer. ISBN 9783030393427

Abstract

This paper presents a preliminary study on macrophages migration in Drosophila embryos, comparing two types of cells. The study is carried out by a framework called macrosight which analyses the movement and interaction of migrating macrophages. The framework incorporates a segmentation and tracking algorithm into analysing motion characteristics of cells after contact. In this particular study, the interactions between cells is characterised in the case of control embryos and Shot3 mutants, where the cells have been altered to suppress a specific protein, looking to understand what drives the movement. Statistical significance between control and mutant cells was found when comparing the direction of motion after contact in specific conditions. Such discoveries provide insights for future developments in combining biological experiments to computational analysis.

Publication Type: Conference or Workshop Item (Paper)
Additional Information: The final authenticated version is available online at https://doi.org/10.1007/978-3-030-39343-4_40
Publisher Keywords: Segmentation, Cell tracking, Track analysis, Macrophages
Subjects: R Medicine > RA Public aspects of medicine
T Technology > TK Electrical engineering. Electronics Nuclear engineering
Departments: School of Mathematics, Computer Science & Engineering > Engineering > Electrical & Electronic Engineering
URI: https://openaccess.city.ac.uk/id/eprint/23849
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