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Disrupted auto-activation, dysexecutive and confabulating syndrome following bilateral thalamic and right putaminal stroke

De Witte, L., Engelborghs, S., Verhoeven, J., De Deyn, P. P. and Marien, P. (2008). Disrupted auto-activation, dysexecutive and confabulating syndrome following bilateral thalamic and right putaminal stroke. Behavioural Neurology, 19(3), 693671.. doi: 10.1155/2008/693671

Abstract

Objective: Clinical, neuropsychological, structural and functional neuroimaging results are reported in a patient who developed a unique combination of symptoms after a bi-thalamic and right putaminal stroke. The symptoms consisted of dysexecutive disturbances associated with confabulating behavior and auto-activation deficits.

Background: Basal ganglia and thalamic lesions may result in a variety of motor, sensory, neuropsychological and behavioral syndromes. However, the combination of a dysexecutive syndrome complicated at the behavioral level with an auto-activation and confabulatory syndrome has never been reported.

Methods: Besides clinical and neuroradiological investigations, an extensive set of standardized neuropsychological tests was carried out.

Results: In the post-acute phase of the stroke, a dysexecutive syndrome was found in association with confabulating behavior and auto-activation deficits. MRI showed focal destruction of both thalami and the right putamen. Quantified ECD SPECT revealed bilateral hypoperfusions in the basal ganglia and thalamus but no perfusion deficits were found at the cortical level.

Conclusion: The combination of disrupted auto-activation, dysexecutive and confabulating syndrome in a single patient following isolated subcortical damage renders this case exceptional. Although these findings do not reveal a functional disruption of the striato-ventral pallidal-thalamic-frontomesial limbic circuitry, they add to the understanding of the functional role of the basal ganglia in cognitive and behavioral syndromes.

Publication Type: Article
Additional Information: Copyright © 2008 Hindawi Publishing Corporation and the authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Publisher Keywords: Putamen, bithalamic stroke, confabulatory syndrome, dysexecutive syndrome, psychic akinesia
Subjects: R Medicine > RC Internal medicine
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Departments: School of Health Sciences > Language & Communication Science
Date Deposited: 27 Nov 2020 11:21
URI: https://openaccess.city.ac.uk/id/eprint/25283
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