City Research Online

Decision-making ability, psychopathology, and brain connectivity

Moutoussis, M., Garzón, B., Neufeld, S., Bach, D., Rigoli, F. ORCID: 0000-0003-2233-934X, Goodyer, I. M., Bullmore, E. T., Guitart-Masip, M., Dolan, R. J., Fonagy, P., Jones, P., Hauser, T., Romero-Garcia, R., St Clair, M., Vértes, P., Whitaker, K. L., Inkster, B., Prabhu, G., Ooi, C., Toseeb, U., Widmer, B., Bhatti, J., Villis, L., Alrumaithi, A., Birt, S., Bowler, A., Cleridou, K., Dadabhoy, H., Davies, E., Firkins, A., Granville, S., Harding, E., Hopkins, A., Isaacs, D., King, J., Kokorikou, D., Maurice, C., McIntosh, C., Memarzia, J., Mills, H., O’Donnell, C., Pantaleone, S., Scott, J., Fearon, P., Suckling, J., van Harmelen, A-L. and Kievit, R. (2021). Decision-making ability, psychopathology, and brain connectivity. Neuron, 109(12), pp. 2025-2040. doi: 10.1016/j.neuron.2021.04.019

Abstract

Decision-making is a cognitive process of central importance for the quality of our lives. Here, we ask whether a common factor underpins our diverse decision-making abilities. We obtained 32 decision-making measures from 830 young people and identified a common factor that we call “decision acuity,” which was distinct from IQ and reflected a generic decision-making ability. Decision acuity was decreased in those with aberrant thinking and low general social functioning. Crucially, decision acuity and IQ had dissociable brain signatures, in terms of their associated neural networks of resting-state functional connectivity. Decision acuity was reliably measured, and its relationship with functional connectivity was also stable when measured in the same individuals 18 months later. Thus, our behavioral and brain data identify a new cognitive construct that underpins decision-making ability across multiple domains. This construct may be important for understanding mental health, particularly regarding poor social function and aberrant thought patterns.

Publication Type: Article
Additional Information: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Publisher Keywords: decision acuity, computational psychiatry, functional connectivity, adolescence, development
Subjects: B Philosophy. Psychology. Religion > BF Psychology
H Social Sciences > HN Social history and conditions. Social problems. Social reform
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Departments: School of Arts & Social Sciences > Psychology
Date available in CRO: 24 May 2021 12:20
Date deposited: 24 May 2021
Date of acceptance: 19 April 2021
Date of first online publication: 20 May 2021
URI: https://openaccess.city.ac.uk/id/eprint/26192
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