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A novel quantitative analysis method for idiopathic epiretinal membrane

Allegrini, D., Montesano, G., Marconi, S., Rosso, N., Ometto, G., Raimondi, R., Auricchio, F., Tsoutsanis, P., Semeraro, F., Cacciatori, M., Crabb, D. P. ORCID: 0000-0001-8754-3902 and Romano, M. R. (2021). A novel quantitative analysis method for idiopathic epiretinal membrane. PLoS ONE, 16(3), e0247192. doi: 10.1371/journal.pone.0247192

Abstract

Purpose
To introduce a novel method to quantitively analyse in three dimensions traction forces in a vast area of the ocular posterior pole.

Methods
Retrospective analysis of 14 eyes who underwent peeling surgery for idiopathic, symptomatic and progressive epiretinal membrane. The technique measures the shift in position of vascular crossings after surgery from a fixed point, which is the retinal pigmented epithelium. This shift is defined as the relaxation index (RI) and represents a measure of the post-operative movement of the retina due to released traction after surgery.

Results
Best-corrected visual acuity was significantly better than baseline at all follow ups while the RI had its maximum value at baseline. Moreover, we found a significant correlation between best-corrected visual acuity at 6 months and RI at baseline.

Conclusion
While all previous published methods focused on bidimensional changes observed in a small region, this study introduces a three-dimensional assessment of tractional forces. Future integration of RI into built-in processing software will allow systematic three-dimensional measurement of intra retinal traction.

Publication Type: Article
Additional Information: Copyright: © 2021 Allegrini et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Subjects: R Medicine > RE Ophthalmology
Departments: School of Health Sciences > Optometry & Visual Science
Date available in CRO: 30 Jun 2021 08:33
Date deposited: 30 June 2021
Date of acceptance: 2 February 2021
Date of first online publication: 17 March 2021
URI: https://openaccess.city.ac.uk/id/eprint/26340
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