City Research Online

Associations with Corneal Hysteresis in a Population Cohort: Results from 96010 UK Biobank Participants

Zhang, B., Shweikh, Y., Khawaja, A. P. , Gallacher, J., Bauermeister, S., Foster, P. J., UKBiobank Eye and Vision Consortium & Crabb, D. P. ORCID: 0000-0001-8754-3902 (2019). Associations with Corneal Hysteresis in a Population Cohort: Results from 96010 UK Biobank Participants. Ophthalmology, 126(11), pp. 1500-1510. doi: 10.1016/j.ophtha.2019.06.029


PURPOSE: To describe the distribution of corneal hysteresis (CH) in a large cohort and explore its associated factors and possible clinical applications.

DESIGN: Cross-sectional study within the UK Biobank, a large cohort study in the United Kingdom.

PARTICIPANTS: We analyzed CH data from 93 345 eligible participants in the UK Biobank cohort, aged 40 to 69 years.

METHODS: All analyses were performed using left eye data. Linear regression models were used to evaluate associations between CH and demographic, lifestyle, ocular, and systemic variables. Piecewise logistic regression models were used to explore the relationship between self-reported glaucoma and CH.

MAIN OUTCOME MEASURES: Corneal hysteresis (mmHg).

RESULTS: The mean CH was 10.6 mmHg (10.4 mmHg in male and 10.8 mmHg in female participants). After adjusting for covariables, CH was significantly negatively associated with male sex, age, black ethnicity, self-reported glaucoma, diastolic blood pressure, and height. Corneal hysteresis was significantly positively associated with smoking, hyperopia, diabetes, systemic lupus erythematosus (SLE), greater deprivation (Townsend index), and Goldmann-correlated intraocular pressure (IOPg). Self-reported glaucoma and CH were significantly associated when CH was less than 10.1 mmHg (odds ratio, 0.86; 95% confidence interval, 0.79-0.94 per mmHg CH increase) after adjusting for covariables. When CH exceeded 10.1 mmHg, there was no significant association between CH and self-reported glaucoma.

CONCLUSIONS: In our analyses, CH was significantly associated with factors including age, sex, and ethnicity, which should be taken into account when interpreting CH values. In our cohort, lower CH was significantly associated with a higher prevalence of self-reported glaucoma when CH was less than 10.1 mmHg. Corneal hysteresis may serve as a biomarker aiding glaucoma case detection.

Publication Type: Article
Additional Information: © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license This article has been published in Ophthalmology: Journal of The American Academy of Ophthalmology by Elsevier, DOI:
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RE Ophthalmology
Departments: School of Health & Psychological Sciences > Optometry & Visual Sciences
SWORD Depositor:
[thumbnail of Clean copy 2019 03 - UK Biobank Corneal Hysteresis PF final draft v2.pdf]
Text - Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (944kB) | Preview


Add to AnyAdd to TwitterAdd to FacebookAdd to LinkedinAdd to PinterestAdd to Email


Downloads per month over past year

View more statistics

Actions (login required)

Admin Login Admin Login