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Stimulus-dependent relationships between behavioral choice and sensory neural responses

Chicharro, D. ORCID: 0000-0002-4038-258X, Panzeri, S. and Haefner, R. M. (2021). Stimulus-dependent relationships between behavioral choice and sensory neural responses. Elife, 10, e54858. doi: 10.7554/eLife.54858

Abstract

Understanding perceptual decision-making requires linking sensory neural responses to behavioral choices. In two-choice tasks, activity-choice covariations are commonly quantified with a single measure of choice probability (CP), without characterizing their changes across stimulus levels. We provide theoretical conditions for stimulus dependencies of activity-choice covariations. Assuming a general decision-threshold model, which comprises both feedforward and feedback processing and allows for a stimulus-modulated neural population covariance, we analytically predict a very general and previously unreported stimulus dependence of CPs. We develop new tools, including refined analyses of CPs and generalized linear models with stimulus-choice interactions, which accurately assess the stimulus- or choice-driven signals of each neuron, characterizing stimulus-dependent patterns of choice-related signals. With these tools, we analyze CPs of macaque MT neurons during a motion discrimination task. Our analysis provides preliminary empirical evidence for the promise of studying stimulus dependencies of choice-related signals, encouraging further assessment in wider data sets.

Publication Type: Article
Additional Information: Copyright Chicharro et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Departments: School of Mathematics, Computer Science & Engineering > Computer Science
Date available in CRO: 09 Nov 2021 09:20
Date deposited: 9 November 2021
Date of acceptance: 6 April 2021
Date of first online publication: 7 April 2021
URI: https://openaccess.city.ac.uk/id/eprint/27075
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