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Two-year visual field outcomes of the treatment for advanced glaucoma study (TAGS)

Montesano, G., Ometto, G. ORCID: 0000-0002-0900-4847, King, A. , Garway-Heath, D. F. & Crabb, D. P. ORCID: 0000-0001-8611-1155 (2022). Two-year visual field outcomes of the treatment for advanced glaucoma study (TAGS). American Journal of Ophthalmology, doi: 10.1016/j.ajo.2022.09.011


to compare visual field (VF) progression between the two arms of the Treatment of Advanced Glaucoma Study (TAGS)

post-hoc analysis of VF data from a two-arm multicenter randomized controlled clinical trial

453 patients with newly diagnosed advanced open-angle glaucoma in at least one eye from 27 centers in the United Kingdom were randomized to either trabeculectomy (N = 227) or medications in their index eye (N = 226) and followed-up for two years with two 24-2 VF tests at baseline, 4, 12 and 24 months. We analyzed data for participants with a reliable VF (False positive rate < 15%) at baseline and at least two other time-points.

Main Outcome Measures
Average difference in rate of progression (RoP) was analyzed using a hierarchical Bayesian model. Time for each eye to progress from baseline beyond specific cut-offs (0.5, 1, 1.5 and 2 dB) was compared using survival analysis.

211 eyes in the trabeculectomy-first arm and 203 eyes in the medications-first arm were analyzed. The average RoPs (Estimate [95% Credible Intervals]) were -0.59 [-0.88, -0.31] dB/year in the medications-first arm and -0.40 [-0.67, -0.13] dB/year in the trabeculectomy-first arm. The difference was not significant (Bayesian p-value = 0.353). More eyes progressed in the medications-first arm: ≥0.5 dB (p = 0.001), ≥1dB (p = 0.014), ≥1.5dB (p = 0.071) and ≥2dB (p = 0.061).

there was no significant difference in the average RoP at two years. Initial trabeculectomy significantly reduced the proportion of progressing eyes.

Publication Type: Article
Additional Information: This is an open access article distributed under the terms of the Creative Commons CC-BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Departments: School of Health & Psychological Sciences > Optometry & Visual Sciences
Text - Accepted Version
Available under License Creative Commons Attribution.

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