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Curcumin in Retinal Diseases: A Comprehensive Review from Bench to Bedside

Allegrini, D., Raimondi, R., Borgia, A. , Sorrentino, T., Montesano, G. ORCID: 0000-0002-9148-2804, Tsoutsanis, P., Cancian, G., Verma, Y., De Rosa, F. P. & Romano, M. R. (2022). Curcumin in Retinal Diseases: A Comprehensive Review from Bench to Bedside. International Journal of Molecular Sciences, 23(7), 3557. doi: 10.3390/ijms23073557

Abstract

Recent evidence in basic science is leading to a growing interest in the possible role of curcumin in treating retinal diseases. Curcumin has been demonstrated to be able to modulate gene transcription and reduce ganglion cell apoptosis, downgrade VEGF, modulate glucose levels and decrease vascular dysfunction. So far, the use of curcumin has been limited by poor bioavailability; to overcome this issue, different types of carriers have been used. Multiple recent studies disclosed the efficacy of using curcumin in treating different retinal conditions. The aim of this review is to comprehensively review and discuss the role of curcumin in retinal diseases from bench to bedside.

Publication Type: Article
Additional Information: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Publisher Keywords: curcumin; review; carrier; diabetic retinopathy; retinitis pigmentosa; macular degeneration
Subjects: R Medicine > RE Ophthalmology
Departments: School of Health & Psychological Sciences > Optometry & Visual Sciences
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