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Cytoelectric coupling: Electric fields sculpt neural activity and "tune" the brain's infrastructure

Pinotsis, D. A. ORCID: 0000-0002-6865-8103, Fridman, G. & Miller, E. K. (2023). Cytoelectric coupling: Electric fields sculpt neural activity and "tune" the brain's infrastructure. Progress in Neurobiology, 226, article number 102465. doi: 10.1016/j.pneurobio.2023.102465


We propose and present converging evidence for the Cytoelectric Coupling Hypothesis: Electric fields generated by neurons are causal down to the level of the cytoskeleton. This could be achieved via electrodiffusion and mechanotransduction and exchanges between electrical, potential and chemical energy. Ephaptic coupling organizes neural activity, forming neural ensembles at the macroscale level. This information propagates to the neuron level, affecting spiking, and down to molecular level to stabilize the cytoskeleton, "tuning" it to process information more efficiently.

Publication Type: Article
Additional Information: © 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (
Publisher Keywords: Memory engrams, Bioelectric field, Ephaptic coupling, Cytoskeleton, Mechanotransduction, Electrodiffusion
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Departments: School of Health & Psychological Sciences > Psychology
SWORD Depositor:
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