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Non-invasive monitoring of intracranial pressure changes: healthy volunteers study

Roldán, M., Bradley, G. R. E., Mejía-Mejía, E. , Abay, T. Y. & Kyriacou, P. A. ORCID: 0000-0002-2868-485X (2023). Non-invasive monitoring of intracranial pressure changes: healthy volunteers study. Frontiers in Physiology, 14, article number 1208010. doi: 10.3389/fphys.2023.1208010


Objective: This research aims to evaluate the possible association between pulsatile near infrared spectroscopic waveform features and induced changes in intracranial pressure in healthy volunteers.

Methods: An optical intracranial pressure sensor was attached to the forehead of 16 healthy volunteers. Pulsatile near infrared spectroscopic signals were acquired from the forehead during body position changes and Valsalva manoeuvers. Features were extracted from the pulsatile signals and analyses were carried out to investigate the presence of statistical differences in the features when intracranial pressure changes were induced. Classification models were developed utilizing the features extracted from the pulsatile near-infrared spectroscopic signals to classify between different body positions and Valsalva manoeuvre.

Results: The presence of significant differences in the majority of the analyzed features (p <
0.05) indicates the technique’s ability to distinguish between variations in intracranial pressure. Furthermore, the disparities observed in the optical signal features captured by the proximal and distal photodetectors support the hypothesis that alterations in back-scattered light directly correspond to brain-related changes. Further research is required to subtract distal and proximal signals and construct predictive models employing a gold standard measurement for non-invasive, continuous monitoring of intracranial pressure.

Conclusion: The study investigated the use of pulsatile near infrared spectroscopic signals to detect changes in intracranial pressure in healthy volunteers. The results revealed significant differences in the features extracted from these signals, demonstrating a correlation with ICP changes induced by positional changes and Valsalva manoeuvre. Classification models were capable of identifying changes in ICP using features from optical signals from the brain, with a sensitivity ranging from 63.07% to 80% and specificity ranging from 60.23% to 70% respectively. These findings underscored the potential of these features to effectively identify alterations in ICP.

Significance: The study’s results demonstrate the feasibility of using features extracted from optical signals from the brain to detect changes in ICP induced by positional changes and Valsalva manoeuvre in healthy volunteers. This represents a first step towards the non-invasive monitoring of intracranial pressure.

Publication Type: Article
Additional Information: © 2023 Roldan, Bradley, Mejía-Mejía, Abay and Kyriacou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Publisher Keywords: intracranial pressure, photoplethysmography, near infrared spectroscopy, brain monitoring, machine learning
Subjects: R Medicine > RC Internal medicine
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
T Technology
Departments: School of Science & Technology > Engineering
SWORD Depositor:
[thumbnail of 2023 M Roldan et al Non-invasive monitoring of intracranial pressure changes healthy volunteers study Frontiers Physiology.pdf]
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Available under License Creative Commons: Attribution International Public License 4.0.

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