Automated quantification of uveitic keratic precipitates by use of anterior segment optical coherence tomography
Pichi, F., Ometto, G. 
ORCID: 0000-0002-0900-4847, Invernizzi, A. , Hay, S., Chaudhry, H., Aljneibi, S., Montesano, G. ORCID: 0000-0002-9148-2804, Zicarelli, F. & Neri, P. (2023).
Automated quantification of uveitic keratic precipitates by use of anterior segment optical coherence tomography.
Clinical & Experimental Ophthalmology, 51(8),
pp. 790-798.
doi: 10.1111/ceo.14296
Abstract
BACKGROUND: Evaluation of ocular inflammation via common imaging modalities like optical coherence tomography (OCT) has emphasised cell visualisation, but automated detection of uveitic keratic precipitates (KPs) remains unexplored.
METHODS: Anterior segment (AS)-OCT dense volumes of the corneas of patients with uveitic KPs were collected at three timepoints: with active (T0), clinically improving (T1), and resolved (T2) inflammation. At each visit, visual acuity and clinical grading of the anterior chamber cells were assessed. A bespoke algorithm was used to create an en face rendering of the KPs and to calculate their volume and a ratio of the volume of precipitates over the analysed area. The variation of AS-OCT-derived measurements over time was assessed, and compared with clinical grading.
RESULTS: Twenty eyes from 20 patients (13 females, mean age 39 years) were studied. At T0, the mean volume of the corneal KPs was 0.1727 mm3 , and it significantly reduced to 0.1111 mm3 (p = 0.03) only at T2. The ratio between the volume of the KPs and the corneal area decreased from T0 (0.007) to T1 (0.006; p = 0.2) and T2 (0.004; p = 0.009). There was a statistically significant correlation between the AC cell count and the AS-OCT volume measurements of the KPs at the three time points.
CONCLUSIONS: AS-OCT can image uveitic KPs and through a bespoke algorithm we were able to create an en face rendering allowing us to extrapolate their volume. We found that objective quantification of KPs correlated with inflammatory cell counts in the anterior chamber.
| Publication Type: | Article |
|---|---|
| Additional Information: | © 2023 The Authors. Clinical & Experimental Ophthalmology published by John Wiley & Sons Australia, Ltd on behalf of Royal Australian and New Zealand College of Ophthalmologists. |
| Publisher Keywords: | anterior segment optical coherence tomography, automated algorithm, keratic precipitates |
| Subjects: | R Medicine > RE Ophthalmology |
| Departments: | School of Policy & Global Affairs > Sociology & Criminology |
| SWORD Depositor: |
Available under License Creative Commons: Attribution International Public License 4.0.
Download (2MB) | Preview
Export
Downloads
Downloads per month over past year
Metadata
MetadataActions (login required)
Admin Login