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An information-theoretic quantification of the content of communication between brain regions

Celotto, M., Bím, J., Tlaie, A. , De Feo, V., Toso, A., Lemke, S. M., Chicharro, D. ORCID: 0000-0002-4038-258X, Nili, H., Bieler, M., Donner, T. H., Hanganu-Opatz, I. L., Brovelli, A. & Panzeri, S. (2023). An information-theoretic quantification of the content of communication between brain regions. In: Oh, A., Naumann, T., Globerson, A. , Saenko, K., Hardt, M. & Levine, S. (Eds.), Advances in Neural Information Processing Systems. NeurIPS 2023, 10-16 Dec 2023, New Orleans, USA.


Quantifying the amount, content and direction of communication between brain regions is key to understanding brain function. Traditional methods to analyze brain activity based on the Wiener-Granger causality principle quantify the overall information propagated by neural activity between simultaneously recorded brain regions, but do not reveal the information flow about specific features of interest (such as sensory stimuli). Here, we develop a new information theoretic measure termed Feature-specific Information Transfer (FIT), quantifying how much information about a specific feature flows between two regions. FIT merges the Wiener-Granger causality principle with information-content specificity. We first derive FIT and prove analytically its key properties. We then illustrate and test them with simulations of neural activity, demonstrating that FIT identifies, within the total information propagated between regions, the information that is transmitted about specific features. We then analyze three neural datasets obtained with different recording methods, magneto- and electro-encephalography, and spiking activity, to demonstrate the ability of FIT to uncover the content and direction of information flow between brain regions beyond what can be discerned with traditional analytical methods. FIT can improve our understanding of how brain regions communicate by uncovering previously unaddressed feature-specific information flow.

Publication Type: Conference or Workshop Item (Paper)
Additional Information: Copyright, the authors, 2023.
Subjects: Q Science > QA Mathematics > QA75 Electronic computers. Computer science
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Departments: School of Science & Technology > Computer Science
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