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Burden of Stroke in Europe: An Analysis of the Global Burden of Disease Study Findings From 2010 to 2019

Prendes, C. F., Rantner, B., Hamwi, T. , Stana, J., Feigin, V. L., Stavroulakis, K., Tsilimparis, N., Fernandez Prendes, C., Rantner, B., Hamwi, T., Stana, J., Feigin, P. V. L., Stavroulakis, K., Tsilimparis, N., Aboyans, P. V., Olusola Akinyemi, R., Al-Shahi Salman, P. R., Artamonov, A. A., Aujayeb, A., Baldereschi, M., Basu, S., Béjot, P. Y., Belo, L., Bennett, D. A., Srikanth Bhagavathula, A., Bikbov, B., Brenner, P. H., Luciano Caetano dos Santos, F., Carrero, P. J. J., Carvalho, P. F., Catapano, P. A. L., Charalampous, P., Christensen, P. H., Chung, S-C., Angelo Cortesi, P., Marisa Costa, V., Cyganska, M., D’Amico, E., Davletov, K., Georgieva Dokova, K., Douiri, A., Francis Fagbamigbe, A., Fischer, F., Ghith, N., Giampaoli, S., Singh Gill, P. P., Gnedovskaya, E. V., Havmoeller, R. J., Hostiuc, S., Iavicoli, P. I., Ilic, P. M. D., Isola, P. G., Jerzy Jozwiak, J., Jürisson, M., Kayode, G. A., Khan, M. A. B., Khatab, P. K., Kisa, P. A., Kivimäki, P. M., Koyanagi, A., Kulimbet, M., Kusuma, D. ORCID: 0000-0002-1909-9341, La Vecchia, P. C., Lacey, B., Lallukka, P. T., Lorkowski, P. S., Majeed, P. A., Giovanni Mantovani, P. L., Mazzaglia, G., Mentis, A-F. A., Meretoja, A., Miao Jonasson, J., Mirica, A., Mirrakhimov, P. E. M., Mohammed, S., Molokhia, M., Monasta, L., Mons, P. U., Morze, J., Irina Negoi, R., Norrving, P. B., Oancea, P. B., O’Caoimh, R., Orru, H., Padron-Monedero, A., Pedersini, P., Perico, N., Polibin, R. V., Polinder, S., Raggi, A., Rawaf, P. S., Remuzzi, P. G., Romoli, M., Sacco, P. S., Reza Saeb, P. M., Vasco Santos, J., Santric-Milicevic, P. M. M., Aleksandrovna Skryabina, A., Smith, L., Starodubova, A. V., Stevanović, A., Stranges, P. S., Teuschl, Y., Topor-Madry, R., Touvier, M., Tovani-Palone, M. R., Unim, B., Juhani Vasankari, P. T., Volovici, V., Wafa, H. A., Wang, Y., Westerman, R., Wolfe, P. C. D. A., Yesiltepe, M., Zanghì, A. & Sergeevich Zastrozhin, P. M. (2024). Burden of Stroke in Europe: An Analysis of the Global Burden of Disease Study Findings From 2010 to 2019. Stroke, 55(2), pp. 432-442. doi: 10.1161/strokeaha.122.042022


While most European Regions perform well in global comparisons, large discrepancies within stroke epidemiological parameters exist across Europe. The objective of this analysis was to evaluate the stroke burden across European regions and countries in 2019 and its difference to 2010.

The GBD 2019 analytical tools were used to evaluate regional and country-specific estimates of incidence, prevalence, deaths, and disability-adjusted life years of stroke for the European Region as defined by the World Health Organization, with its 53 member countries (EU-53) and for European Union as defined in 2019, with its 28 member countries (EU-28), between 2010 and 2019. Results were analyzed at a regional, subregional, and country level.

In EU-53, the absolute number of incident and prevalent strokes increased by 2% (uncertainty interval [UI], 0%–4%), from 1 767 280 to 1 802 559 new cases, and by 4% (UI, 3%–5%) between 2010 and 2019, respectively. In EU-28, the absolute number of prevalent strokes and stroke-related deaths increased by 4% (UI, 2%–5%) and by 6% (UI, 1%–10%), respectively. All-stroke age-standardized mortality rates, however, decreased by 18% (UI, −22% to −14%), from 82 to 67 per 100 000 people in the EU-53, and by 15% (UI, −18% to −11%), from 49.3 to 42.0 per 100 000 people in EU-28. Despite most countries presenting reductions in age-adjusted incidence, prevalence, mortality, and disability-adjusted life year rates, these rates remained 1.4×, 1.2×, 1.6×, and 1.7× higher in EU-53 in comparison to the EU-28.

EU-53 showed a 2% increase in incident strokes, while they remained stable in EU-28. Age-standardized rates were consistently lower for all-stroke burden parameters in EU-28 in comparison to EU-53, and huge discrepancies in incidence, prevalence, mortality, and disability-adjusted life-year rates were observed between individual countries.

Publication Type: Article
Additional Information: This article has been published in Stroke by Lippincott, Williams & Wilkins on 22 Jan 2024 and it's available at:
Publisher Keywords: GBD Collaborators Study Group, Humans, Uncertainty, World Health Organization, Europe, Stroke, Global Burden of Disease, Europe, World Health Organization, global burden of disease, global health, stroke, Humans, Global Burden of Disease, Europe, Stroke, Uncertainty, World Health Organization, 1102 Cardiorespiratory Medicine and Haematology, 1103 Clinical Sciences, 1109 Neurosciences, Neurology & Neurosurgery
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Departments: School of Health & Psychological Sciences
School of Health & Psychological Sciences > Healthcare Services Research & Management
SWORD Depositor:
[thumbnail of Prendes 2024 accepted version.pdf] Text - Accepted Version
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