City Research Online

Abstract

Introduction: Faecal microbiota transplantation (FMT) is an emerging treatment for Clostridioides difficile infection (CDI) through reconstruction of the gut microbiota, but its impact in people with spinal cord injury (PWSCI) is limited. The aim of this paper is to (1) report the use of FMT in a PWSCI with CDI. Methods: the FMT was conducted on 30th October 2019.
Results: A 72-year-old man with T8 complete paraplegia from compression of the spinal cord due to an epidural haematoma was referred. He has known severe pancreatic enzyme insufficiency, malabsorption and a history of recurrent CDI. Despite intensive dietetic treatment (probiotics, enteral- and parenteral-nutrition), and multiple courses of antibiotics (vancomycin and fidaxomicin at various doses and durations) for CDI, he continued to be CDI positive. His CDI was successful treated after two colonoscopically delivered FMT. At 24 months’ follow-up, he remains CDI negative and reports an improved independence. Although, there has been considerable variability in the criteria for the FMT and its mode of delivery, FMT can be an option to treat recurrent CDI.
Discussion: This case report reports a PWSCI with recurrent CDI who has been successfully treated with FMT and remains in long-term remission. It supports the consideration of FMT in PWSCI with CDI when antibiotic treatment has been unsuccessful.

Publication Type:	Article
Additional Information:	This article has been accepted for publication in Journal of the International Society of Physical and Rehabilitation Medicine and it will be available online at: https://journals.lww.com/jisprm/pages/default.aspx
Publisher Keywords:	Spinal cord injury; Faecal microbiota transplant; Microbiota; Clostridioides difficile;
Subjects:	R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RC Internal medicine
Departments:	School of Health & Psychological Sciences School of Health & Psychological Sciences > Healthcare Services Research & Management
SWORD Depositor:	Symplectic Administrator

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