City Research Online

Abstract

Traumatic brain injury (TBI) affects approximately 70 million individuals annually worldwide, often leading to significant morbidity and mortality. Intracranial pressure (ICP) monitoring plays a vital role in managing severe TBI and other conditions associated with intracranial hypertension by guiding timely medical interventions. However, invasive ICP monitoring requires drilling the skull to place a sensor transducer inside the head, also called a probe. Noninvasive ICP monitoring offers the potential to monitor patients during the critical "golden hour," when timely interventions can significantly influence outcomes. Additionally, it enables continuous surveillance for patients who are not candidates for invasive bolt placement. However, a reliable, continuous, noninvasive ICP measurement remains aspirational despite extensive research efforts. Crainio has developed a noninvasive ICP monitoring system utilising an optical sensor adhered to the forehead. This monitor collects cerebral photoplethysmography signals to estimate ICP changes and detect hypertension, enabling early management and improved patient outcomes. This feasibility study aims to improve the diagnostic precision of Crainio’s algorithm by augmenting the existing dataset, which currently comprises data from 40 TBI patients. A total of 54 participants will be enrolled over one year. Data from simultaneous recordings from the optical sensor and invasive ICP monitors create a more robust dataset to refine and optimise the algorithm for greater clinical accuracy. Additionally, the study will investigate the influence of potential confounders. The ultimate objective is to establish a robust noninvasive monitoring tool to optimize the management of TBI patients, advancing both safety and efficacy in ICP monitoring.

Publication Type:	Article
Additional Information:	Published in ScienceBank under a Creative Commons Licence CC-BY 4.0.
Publisher Keywords:	Intracranial pressure, Non-invasive monitoring, Traumatic brain injury, Photoplethysmography.
Subjects:	R Medicine > R Medicine (General)
Departments:	School of Science & Technology School of Science & Technology > Department of Engineering
SWORD Depositor:	Symplectic Administrator

Export

Downloads