Archetypes of Binocular Visual Field Loss and Their Impact on Vision-Related Quality of Life in Glaucoma Patients
Gazanchian, M., Nejad, A., Crabb, D. P. 
ORCID: 0000-0001-8754-3902 , Montesano, G. ORCID: 0000-0002-9148-2804 & Jansonius, N. M. (2026).
Archetypes of Binocular Visual Field Loss and Their Impact on Vision-Related Quality of Life in Glaucoma Patients.
Investigative Ophthalmology & Visual Science, 67(3),
article number 28.
doi: 10.1167/iovs.67.3.28
Abstract
PURPOSE. Binocular visual field (VF) loss affects vision-related quality of life (VR-QoL) but the relationship between specific VF loss patterns and difficulties with specific tasks remains poorly understood. Archetypal analysis offers a promising method to elucidate spatial patterns of VF loss. In this study, we aimed to develop archetypes for binocular VF loss and assess their relationship with VR-QoL.
METHODS. We included 7305 pairs of reliable standard automated perimetry (24-2 SITA fast and standard) test results of patients from 5 glaucoma clinics in England from a Healthcare Quality Improvement Partnership-funded audit. We executed an archetypal analysis on the corresponding integrated VFs (estimates of the binocular VFs from pairs of monocular VFs) to identify the best-fitting set of archetypes from our dataset. Then, we used these archetypes to deconstruct the binocular VF of 269 patients with glaucoma from the Netherlands that had completed 4 different VR-QoL questionnaires. Finally, relationships between each of the archetypes and different aspects of VR-QoL were analyzed.
RESULTS. The archetypal analysis demonstrated that a solution comprising 12 archetypes provides the best-fitting model. Our analysis of the 269 patients’ with glaucoma data showed various significant and plausible relationships between the different archetypes and various aspects of VR-QoL.
CONCLUSIONS. Our results demonstrate how archetypes can elucidate relationships between the location of a VF defect and different aspects of VR-QoL in glaucoma. This may help clinicians and patients better understand the impact of different types of VF defects.
| Publication Type: | Article |
|---|---|
| Additional Information: | Copyright 2026 The Authors. This work is licensed under a Creative Commons Attribution 4.0 International License. |
| Publisher Keywords: | glaucoma, visual field (VF) defect, archetypes, quality of life (QoL) |
| Subjects: | R Medicine > RE Ophthalmology |
| Departments: | School of Health & Medical Sciences School of Health & Medical Sciences > Department of Optometry & Visual Science |
| SWORD Depositor: |
Available under License Creative Commons Attribution.
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