City Research Online

Abstract

Rationale
Healthy adults increasingly use drugs to enhance cognitive performance. However, these drugs influence brain systems that have also been associated with dishonesty. Given the prevalent use of potentially performance-enhancing drugs in contexts susceptible to cheating, it is crucial to ascertain whether they have adverse effects on honesty.

Objectives
Our primary objective was to compare the effects of methylphenidate with those of placebo to determine the direction and magnitude of its potential influence on dishonest behavior. We furthermore examined the intuitions of people who use smart drugs about the effects of methylphenidate on cheating in a US representative sample.

Methods
We conducted a double-blind, placebo-controlled experiment to compare the effects of methylphenidate (Ritalin), a popular performance-enhancing drug, and compared its effects with atomoxetine (Strattera), another performance-enhancing drug with a distinct pharmacological mechanism. Participants were randomly assigned to receive either a placebo (n = 52), methylphenidate (n = 49), or atomoxetine (n = 50). Subsequently, they performed a die-rolling task in which they could increase their earnings by dishonestly misreporting their outcomes. Additionally, a representative sample of 575 American participants indicated their performance-enhancing drugs use and intuitions about the effects of these drugs on dishonesty.

Results
Our findings show that, compared to the placebo condition, methylphenidate reduced dishonesty. This effect was not attributable to statistical fluctuations, demand effects, or domain-general mechanisms such as mood or attention. In addition, individuals who use drugs to enhance performance have limited intuitions about the impact of methylphenidate on dishonest behavior.

Conclusion
These results reveal an unforeseen consequence associated with methylphenidate and may have policy implications regarding the paradoxical relationship between the use of drugs for performance enhancement and their potential impact on honesty.

Publication Type:	Article
Additional Information:	This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Publisher Keywords:	Methylphenidate, Atomoxetine, Performance-enhancing drugs, Cheating, Attention, Bioethics
Subjects:	B Philosophy. Psychology. Religion > BF Psychology H Social Sciences > HN Social history and conditions. Social problems. Social reform R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Departments:	School of Health & Medical Sciences School of Health & Medical Sciences > Department of Psychology & Neuroscience
SWORD Depositor:	Symplectic Administrator

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