Clinical manifestations of human monkeypox infection and implications for outbreak strategy
Johri, N. 
ORCID: 0000-0002-9212-6043, Kumar, D., Nagar, P. , Maurya, A., Vengat, M. & Jain, P. (2022).
Clinical manifestations of human monkeypox infection and implications for outbreak strategy.
Health Sciences Review, 5,
article number 100055.
doi: 10.1016/j.hsr.2022.100055
Abstract
Monkeypox is an orthopoxvirus-based zoonotic illness that causes symptoms similar to smallpox in humans. Health care workers around the world are making it a priority to educate themselves on the many clinical manifestations and treatment options for this virus as public health agencies strive to stop the current outbreak. The infected do not have access to any treatment at this time. However, information obtained from the smallpox pandemic has led researchers to examine vaccinia immune globulin (IVG), tecovirimat, and cidofovir as viable treatments for monkeypox. Moreover, medication like tecovirimat may be given in extreme circumstances, and supportive therapy can help with symptom relief. The European Medicines Agency (EMA) certified tecovirimat as safe and effective against monkeypox in 2022, per the World Health Organization (WHO). As there are now no established guidelines for alleviating these symptoms, the efficacy of these treatments is highly questionable. Some high-profile cases in recent years have cast doubt on the long-held belief that this illness is rare and always resolves itself without treatment. We aimed to conduct this review to get a deeper comprehension of the evolving epidemiology of monkeypox by analysing such factors as the number of confirmed, probable, and potential cases, the median age at presentation, the mortality rate, and the geographic distribution of the disease. This study offers an updated review of monkeypox and the clinical treatments that are currently available as a result of the worldwide epidemics.
| Publication Type: | Article |
|---|---|
| Additional Information: | © 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Publisher Keywords: | Disease outbreaks, Monkeypox, Orthopoxvirus, Poxviridae, Zoonosis |
| Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Departments: | School of Health & Medical Sciences School of Health & Medical Sciences > Department of Allied Health |
| SWORD Depositor: |
Available under License Creative Commons Attribution.
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