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Spectrophotometric analysis of Lithium Carbonate used for Bipolar Disorder

May, J.M., Hickey, M., Triantis, I. , Palazidou, E. & Kyriacou, P. A. (2015). Spectrophotometric analysis of Lithium Carbonate used for Bipolar Disorder. Biomedical Optics Express, 6(3), pp. 1067-1073. doi: 10.1364/boe.6.001067


Lithium therapy is the gold standard of treatment for patients with Bipolar Disorder. However, despite its effectiveness, it is a potentially hazardous drug requiring regular monitoring of blood levels to ensure toxic levels are not reached. This paper describes the spectrophotometric analysis of Lithium carbonate in solution as a first step in developing a portable home monitoring device for blood lithium analysis.. Using a high-end spectrophotometer, solutions of lithium carbonate (Li2CO3) have been optically fingerprinted. Preliminary measurements indicate that the ultraviolet region shows a strong distinction between different lithium concentrations. Utilizing second derivative absorption curves, the region of 220 nm to 230 nm demonstrated the ability to differentiate between concentrations representing those found in patients. Furthermore, the method could determine to within a 1–6% accuracy whether an unknown solution of Li2CO3 is either inside or outside the high-end of the therapeutic limit.

Publication Type: Article
Additional Information: This paper was published in Biomedical Optics Express and is made available as an electronic reprint with the permission of OSA. The paper can be found at the following URL on the OSA website: Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law.
Subjects: T Technology > TA Engineering (General). Civil engineering (General)
Departments: School of Science & Technology > Engineering
SWORD Depositor:
[thumbnail of BioOpticsExp-V6Iss3-Mar1-2015_J-M-MAY_M-HICKEY_I-TRIANTIS_E-PALAZIDOU_P-AKYRIACOU_.pdf]
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