City Research Online

Grammar disruption in a patient with Neuro-Sweet syndrome

Marien, P., Tops, W., Crols, R. , Jonkers, R., De Deyn, P. P. & Verhoeven, J. (2012). Grammar disruption in a patient with Neuro-Sweet syndrome. Neurocase, 18(3), pp. 235-247. doi: 10.1080/13554794.2011.588178


This paper for the first time reports detailed neurolinguistic findings in a patient with Neuro-Sweet syndrome. In this patient the presenting symptoms of central nervous system (CNS) involvement primarily consisted of a selective grammar deficit restricted to spontaneous speech. On MRI a left prefrontal ischemic stroke (superior part BA 6) and two small subcortical left parietal infarctions were found. Neurolinguistic analyses, however, did not reveal a profile consistent with any observations of agrammatism caused by structural damage to the language areas critically involved in grammatical processing. It is hypothesized that selectively distorted grammar might reflect disruption of the frontosubcortical network involved in language processing. Prefrontal neurobehavioral abnormalities associated with functional disruption of the inferior medial frontal regions as demonstrated by SPECT, additionally suggest that agrammatic symptoms may be linked to a higher-level cognitive disorder following encephalopathic CNS involvement.

Publication Type: Article
Additional Information: This is an Accepted Manuscript of an article published by Taylor & Francis in Neurocase on 1 Sep 2011, available online:
Publisher Keywords: Neuro-Sweet disease, Agrammatism, Language, Cognition, SPECT
Subjects: P Language and Literature > P Philology. Linguistics
Departments: School of Health & Psychological Sciences > Language & Communication Science
Text - Accepted Version
Download (636kB) | Preview



Downloads per month over past year

View more statistics

Actions (login required)

Admin Login Admin Login