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Abstract

Differential Pathlength Factor (DPF) is a vital parameter for the Beer-Lambert law based calculations in estimating tissue perfusion using non-invasive optical techniques. A significant error in the measured concentration of oxyhemoglobin and deoxyhemoglobin has been reported due to the usage of wrong DPF values. The dependence of DPF on blood oxygen saturation and blood volume has never been studied earlier. In this work, a Monte Carlo model of perfused skin tissue was developed and executed at 660 nm and 940 nm optical wavelengths at a reflectance geometry. DPFs were simulated through 1-10 mm source detector separations at different blood volumes and oxygen saturations. Results showed higher DPFs at lower wavelengths and considerable variation with blood volume and oxygen saturation.

Publication Type:	Article
Additional Information:	© 2019 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
Subjects:	R Medicine > R Medicine (General) T Technology > TK Electrical engineering. Electronics Nuclear engineering
Departments:	School of Science & Technology > Engineering

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