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A physiological marker of recognition memory in adults with autism spectrum disorder? The Pupil Old/New Effect

Ring, M., Bowler, D. M. ORCID: 0000-0002-9884-0627 and Gaigg, S. B. ORCID: 0000-0003-2644-7145 (2020). A physiological marker of recognition memory in adults with autism spectrum disorder? The Pupil Old/New Effect. Autism Research: official journal of the International Society for Autism Research, doi: 10.1002/aur.2251

Abstract

This study investigated the pupil Old/New effect in individuals with Autism Spectrum Disorder (ASD) and typical development (TD). Participants studied verbal and visual meaningful and meaningless materials in black and white on a computer screen. Pupil sizes were measured while participants performed a Remember (episodic memory with context) /Know (semantic memory, no context) recognition memory test. ASD compared to TD individuals showed significantly reduced recognition rates for all materials. Both groups showed better memory for visual compared to verbal (picture superiority effect) and meaningful compared to meaningless materials. A pupil size ratio (pupil size for test item divided by baseline) for old (studied) and new (unstudied) materials indicated larger pupils for old compared to new materials only for the TD but not the ASD group. Pupil size in response to old versus new items was positively related to recognition accuracy, confirming that the pupil Old/New effect reflects a memory phenomenon in the ASD group. In addition, this study suggests an involvement of the noradrenergic neurotransmitter system in the abnormal hippocampal functioning in ASD. Implications of these findings as well as their underlying neurophysiology will be discussed in relation to current theories of memory in ASD.

Publication Type: Article
Additional Information: This is the peer reviewed version of the following article Ring, M., Bowler, D. M. and Gaigg, S. B. (2019). A physiological marker of recognition memory in adults with autism spectrum disorder? The Pupil Old/New Effect. Autism Research: official journal of the International Society for Autism Research, : , which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Publisher Keywords: pupil old/new effect, episodic/semantic memory, remember/know recognition procedure, picture superiority effect, autism spectrum disorder
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Departments: School of Arts & Social Sciences > Psychology
Date Deposited: 14 Feb 2020 17:01
URI: https://openaccess.city.ac.uk/id/eprint/23364
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