Associations with photoreceptor thickness measures in the UK Biobank
Chua, S. Y. L., Dhillon, B., Aslam, T. , Balaskas, K., Yang, Q., Keane, P. A., Tufail, A., Reisman, C., Foster, P. J., Patel, P. J., Bishop, P., Barman, S. A., Barrett, J. H., Blows, P., Bunce, C., Carare, R. O., Chakravarthy, U., Chan, M., Crabb, D. P. 
ORCID: 0000-0001-8754-3902, Cumberland, P. M., Day, A., Desai, P., Sudlow, C., Dick, A. D., Egan, C., Ennis, S., Fruttiger, M., Gallacher, J. E. J., Garway-Heath, D. F., Gibson, J., Gore, D., Guggenheim, J. A., Hammond, C. J., Hardcastle, A., Harding, S. P., Hogg, R. E., Hysi, P., Khaw, Sir P. T., Khawaja, A.P., Lascaratos, G., Lotery, A. J., Macgillivray, T., Mackie, S., Martin, K., Mcgaughey, M., Mcguinness, B., Mckay, G. J., Mckibbin, M., Mitry, D., Moore, T., Morgan, J. E., Muthy, Z. A., O'Sullivan, E., Owen, C. G., Paterson, E., Peto, T., Petzold, A., Rahi, J. S., Rudnicka, A. R., Self, J., Sivaprasad, S., Steel, D., Stratton, I., Strouthidis, N., Thaung, C., Thomas, D., Trucco, E., Vitart, V., Vernon, S. A., Viswanathan, A. C., Williams, C., Williams, K., Woodside, J. V., Yates, M. M., Yip, J., Zheng, Y. & Tapp, R. (2019).
Associations with photoreceptor thickness measures in the UK Biobank.
Scientific Reports, 9(1),
article number 19440.
doi: 10.1038/s41598-019-55484-1
Abstract
Spectral-domain OCT (SD-OCT) provides high resolution images enabling identification of individual retinal layers. We included 32,923 participants aged 40–69 years old from UK Biobank. Questionnaires, physical examination, and eye examination including SD-OCT imaging were performed. SD OCT measured photoreceptor layer thickness includes photoreceptor layer thickness: inner nuclear layer-retinal pigment epithelium (INL-RPE) and the specific sublayers of the photoreceptor: inner nuclear layer-external limiting membrane (INL-ELM); external limiting membrane-inner segment outer segment (ELM-ISOS); and inner segment outer segment-retinal pigment epithelium (ISOS-RPE). In multivariate regression models, the total average INL-RPE was observed to be thinner in older aged, females, Black ethnicity, smokers, participants with higher systolic blood pressure, more negative refractive error, lower IOPcc and lower corneal hysteresis. The overall INL-ELM, ELM-ISOS and ISOS-RPE thickness was significantly associated with sex and race. Total average of INL-ELM thickness was additionally associated with age and refractive error, while ELM-ISOS was additionally associated with age, smoking status, SBP and refractive error; and ISOS-RPE was additionally associated with smoking status, IOPcc and corneal hysteresis. Hence, we found novel associations of ethnicity, smoking, systolic blood pressure, refraction, IOPcc and corneal hysteresis with photoreceptor thickness.
| Publication Type: | Article |
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| Additional Information: | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| Publisher Keywords: | Epidemiology; Risk factors |
| Subjects: | R Medicine > RE Ophthalmology |
| Departments: | School of Health & Psychological Sciences > Optometry & Visual Sciences |
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