City Research Online

Abstract

Pulse rate variability (PRV), measured from pulsatile signals such as the photoplethysmogram (PPG), has been largely used in recent years as a surrogate of heart rate variability (HRV), which is measured from electrocardiograms (ECG). However, different studies have shown that PRV does not always replicate HRV as there are multiple factors that could affect their relationship, such as respiration and pulse transit time. In this study, an in-vitro model was developed for the simulation of the upper-circulatory system, and PPG signals were acquired from it when haemodynamic changes were induced. PRV was obtained from these signals and time-domain, frequency-domain and non-linear indices were extracted. Factorial analyses were performed to understand the effects of changing blood pressure and flow on PRV indices in the absence of HRV. Results showed that PRV indices are affected by these haemodynamic changes and that these may explain some of the differences between HRV and PRV. Future studies should aim to replicate these results in healthy volunteers and patients, as well as to include the HRV information in the in-vitro model for a more profound understanding of these differences.

Publication Type:	Article
Additional Information:	Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Publisher Keywords:	pulse rate variability; photoplethysmography; haemodynamics; in-vitro cardiovascular models; vascular tissue phantoms
Subjects:	R Medicine > R Medicine (General) T Technology > TK Electrical engineering. Electronics Nuclear engineering
Departments:	School of Science & Technology > Engineering
SWORD Depositor:	Symplectic Administrator

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