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A survey of open questions in adaptive therapy: Bridging mathematics and clinical translation

West, J. D., Adler, F., Gallaher, J. , Strobl, M., Brady-Nicholls, R., Brown, J., Roberson-Tessi, M., Kim, E., Noble, R. ORCID: 0000-0002-8057-4252, Viossat, Y., Basanta, D. & Anderson, A. (2023). A survey of open questions in adaptive therapy: Bridging mathematics and clinical translation. Elife, 12, article number e84263. doi: 10.7554/elife.84263


Adaptive therapy is a dynamic cancer treatment protocol that updates (or ‘adapts’) treatment decisions in anticipation of evolving tumor dynamics. This broad term encompasses many possible dynamic treatment protocols of patient-specific dose modulation or dose timing. Adaptive therapy maintains high levels of tumor burden to benefit from the competitive suppression of treatment-sensitive subpopulations on treatment-resistant subpopulations. This evolution-based approach to cancer treatment has been integrated into several ongoing or planned clinical trials, including treatment of metastatic castrate resistant prostate cancer, ovarian cancer, and BRAF-mutant melanoma. In the previous few decades, experimental and clinical investigation of adaptive therapy has progressed synergistically with mathematical and computational modeling. In this work, we discuss 11 open questions in cancer adaptive therapy mathematical modeling. The questions are split into three sections: (1) integrating the appropriate components into mathematical models (2) design and validation of dosing protocols, and (3) challenges and opportunities in clinical translation.

Publication Type: Article
Additional Information: Copyright © West et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Subjects: Q Science > QA Mathematics
R Medicine > RC Internal medicine
Departments: School of Science & Technology > Mathematics
SWORD Depositor:
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