City Research Online

Abstract

The correlational structure of brain activity dynamics in the absence of stimuli or behavior is often taken to reveal intrinsic properties of neural function. To test the limits of this assumption, we analyzed peripheral contributions to resting state activity measured by fMRI in unanesthetized, chemically immobilized male rats that emulate human neuroimaging conditions. We find that perturbation of somatosensory input channels modifies correlation strengths that relate somatosensory areas both to one another and to higher-order brain regions, despite the absence of ostensible stimuli or movements. Resting state effects are mediated by the same peripheral and thalamic structures that relay responses to overt sensory stimuli. The impact of basal peripheral input is reduced in a rat model of autism, which displays both lower somatosensory functional connectivity and insensitivity to vibrissa inactivation. These results demonstrate the influence of extrinsic influences on resting state brain phenotypes in health and disease.

Publication Type:	Article
Publisher Keywords:	Brain, Thalamus, Somatosensory Cortex, Vibrissae, Animals, Rats, Rats, Sprague-Dawley, Disease Models, Animal, Magnetic Resonance Imaging, Brain Mapping, Autistic Disorder, Rest, Male, Animals, Magnetic Resonance Imaging, Male, Rats, Brain, Rest, Vibrissae, Autistic Disorder, Brain Mapping, Somatosensory Cortex, Disease Models, Animal, Rats, Sprague-Dawley, Thalamus
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Departments:	School of Health & Psychological Sciences School of Health & Psychological Sciences > Psychology
SWORD Depositor:	Symplectic Administrator

Export

Downloads