City Research Online

Abstract

Hydration status is a critical parameter in maintaining skin health and overall physiological balance, influencing a range of biological processes. This research presents the design, development, and validation of a novel multi-wavelength near-infrared (NIR) optical sensing device, specifically engineered for the accurate and non-invasive measurement of skin and body hydration levels. The research conducted spans comprehensive in silico modelling, controlled in vitro and ex vivo testing, and rigorous in vivo experimentation, ensuring a robust solution for real-time hydration monitoring.

The developed device operates by emitting NIR light at carefully selected wavelengths that correspond to absorption peaks of water molecules within biological tissues. By analysing the reflectance signals from these tissues, the device can accurately quantify water content across different skin layers. This addresses the limitations of existing techniques, which often suffer from inaccuracies due to interference or require invasive procedures. In addition, the multiwavelength approach enhances specificity and depth resolution, providing a more comprehensive assessment of hydration status.

A key component of this research was the development of a calibration model, trained using datasets obtained from the experimental phases and cross-referenced with established hydration metrics. This model incorporates variations in gender, skin types and ethnicities, ensuring accuracy and reliability across a diverse population. The model takes the form of a protocol and device, combining structured workflows and real-time sensor data with user inputs
to generate hydration predictions.

In vivo studies demonstrated the device’s efficacy in tracking hydration changes induced by various factors, including exercise and topical applications of moisturizers. The results showed a high correlation between the device’s readings and traditional hydration assessment methods (R2 skin = 0.76, R2 body = 0.58, validating its potential for clinical and personal use. Moreover, the non-invasive nature of the device makes it ideal for continuous hydration monitoring in dynamic environments, such as during physical activity.

This research represents an advancement in the field of hydration monitoring, offering a new tool that combines the precision of optical sensing with the practicality of wearable technology. The device not only enhances our ability to monitor hydration with greater accuracy but also opens up new possibilities for its application in medical diagnostics, sports science, and dermatological research. The findings and methodologies pave the way for future innovations in non-invasive health monitoring technologies, with the potential to contribute to a greater understanding of hydration-related health issues.

Publication Type:	Thesis (Doctoral)
Subjects:	Q Science > Q Science (General) T Technology > T Technology (General) T Technology > TA Engineering (General). Civil engineering (General)
Departments:	School of Science & Technology > Engineering School of Science & Technology > School of Science & Technology Doctoral Theses Doctoral Theses

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