Modelling the nuclear envelope of HeLa cells
Karabağ, C. 
ORCID: 0000-0003-4424-0471, Jones, M. L., Peddie, C. J. , Weston, A. E., Collinson, L. M. & Reyes-Aldasoro, C. C. ORCID: 0000-0002-9466-2018 (2018).
Modelling the nuclear envelope of HeLa cells.
Cold Spring Harbor Laboratory.
doi: 10.1101/344986
Abstract
This paper describes a framework for the automatic segmentation of the nuclear envelope of cancerous HeLa cells and the modelling of the volumetric shape against an ellipsoid. The framework is automatic and unsupervised and reported a Jaccard Similarity Index of 0.968 against a manual segmentation. The modelling of the surface provides a visual display of the variations, both smooth and rugged over the surface, and measurements can be extracted with the expectation that they can correlate with the biological characteristics of the cells.
| Publication Type: | Other (Preprint) |
|---|---|
| Publisher Keywords: | Automatic Nuclear Segmentation, HeLa Nuclear Shape |
| Subjects: | Q Science > QA Mathematics > QA75 Electronic computers. Computer science Q Science > QC Physics Q Science > QH Natural history > QH301 Biology T Technology > T Technology (General) |
| Departments: | School of Science & Technology School of Science & Technology > Department of Computer Science School of Science & Technology > Department of Computer Science > giCentre |
| SWORD Depositor: |
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