Olanzapine for young PEople with aNorexia nervosa (OPEN): A protocol for an open‐label feasibility study
Said, O., Sengun Filiz, E., Stringer, D. , Applewhite, B., Kellermann, V. 
ORCID: 0009-0004-5969-3769, Mutwalli, H., Bektas, S., Akkese, M. N., Kumar, A., Carter, B., Simic, M., Sually, D., Bentley, J., Young, A. H., Madden, S., Byford, S., Landau, S., Lawrence, V., Treasure, J., Schmidt, U., Nicholls, D. & Himmerich, H. (2024).
Olanzapine for young PEople with aNorexia nervosa (OPEN): A protocol for an open‐label feasibility study.
European Eating Disorders Review, 32(3),
pp. 532-546.
doi: 10.1002/erv.3060
Abstract
Introduction
Antipsychotics are routinely prescribed off‐label for anorexia nervosa (AN) despite limited evidence. This article presents a protocol of a study aiming to assess the feasibility of a future definitive trial on olanzapine in young people with AN.
Methods and analysis
In an open‐label, one‐armed feasibility study, 55 patients with AN or atypical AN, aged 12–24, receiving outpatient, inpatient or day‐care treatment who are considered for olanzapine treatment will be recruited from NHS sites based in England. Assessments will be conducted at screening, baseline and at 8‐, 16 weeks, 6‐ and 12 months. Primary feasibility parameters will be proportions of patients who agree to take olanzapine and who adhere to treatment and complete study assessments. Qualitative methods will be used to explore acceptability of the intervention and study design. Secondary feasibility parameters will be changes in body mass index, psychopathology, side effects, health‐related quality of life, carer burden and proportion of participants who would enrol in a future randomised controlled trial. The study is funded by the National Institute for Health Research via Health Technology Assessment programme.
Discussion
Olanzapine for young PEople with aNorexia nervosa will inform a future randomised controlled trial on the efficacy and safety of prescribing olanzapine in young people with AN.
| Publication Type: | Article |
|---|---|
| Additional Information: | © 2024 The Authors. European Eating Disorders Review published by Eating Disorders Association and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Publisher Keywords: | anorexia nervosa, feasibility, olanzapine, weight restoration |
| Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Departments: | School of Health & Medical Sciences School of Health & Medical Sciences > Department of Nursing & Midwifery |
| SWORD Depositor: |
Available under License Creative Commons Attribution.
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