When effective anticancer therapies are, in fact, destabilizing the tumor’s Group Phenotypic Composition
Thomas, F., M. Dujon, A., Marusyk, A. , DeGregori, J., Fontanella, A., Bieuville, M., Campone, M., Pujol, P., Alix-Panabières, C., Lecam, L., Roche, B., Lacroix, M., Hirtz, C., Poulain, L., Capp, J-P., Ujvari, B., Meliani, J., Noble, R. 
ORCID: 0000-0002-8057-4252, Nedelcu, A. M. & Gatenby, R. (2026).
When effective anticancer therapies are, in fact, destabilizing the tumor’s Group Phenotypic Composition.
npj Precision Oncology,
doi: 10.1038/s41698-026-01536-5
Abstract
Many cancer therapies achieve durable control without complete tumor eradication, suggesting that disrupting tumor organization may be more critical than killing cells. We propose that effective treatments converge by destabilizing the tumor’s Group Phenotypic Composition (GPC), the functional and spatial organization of interacting cell populations. When this organization collapses, tumors lose coherence. This perspective provides a unifying framework for designing therapies targeting tumor-level dynamics rather than cell number alone.
| Publication Type: | Article |
|---|---|
| Additional Information: | © The Authors. Published by Springer. This is an open-access article distributed under the terms of Creative Commons: Attribution International Public License 4.0 (http://creativecommons.org/licenses/by/4.0/). |
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| Departments: | School of Science & Technology School of Science & Technology > Department of Mathematics |
| SWORD Depositor: |
Available under License Creative Commons Attribution.
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