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Dunbar, H. M. P. ORCID: 0000-0002-7149-5122, Crabb, D. P., Behning, C. ORCID: 0000-0002-9310-3804 , Binns, A. M. ORCID: 0000-0001-8621-498X, Abdirahman, A., Terheyden, J. H., Poor MRCOphth, S. ORCID: 0000-0003-4374-1178, Finger, R. P., Leal, S. ORCID: 0000-0001-7870-0478, Tufail, A., Holz, F. G., Schmid, M. & Luhmann, U. F. O.view all authors (2025). Heterogeneous Visual Function Deficits in Intermediate Age-Related Macular Degeneration: A MACUSTAR Report. Ophthalmology Science, 5(4), article number 100708. doi: 10.1016/j.xops.2025.100708

Terheyden, J. H., Holz, F. G., Behning, C. , Dunbar, H. M. P., Schmitz-Valckenberg, S., Tufail, A., Schmid, M., Crabb, D. P. ORCID: 0000-0001-8611-1155, Saßmannshausen, M., Binns, A. ORCID: 0000-0001-8621-498X, Hoyng, C. B., Zakaria, N., Poor, S., Moll, K-P., Cosette, D., Martinho, C., Batuca, J., Cunha-Vaz, J., Luhmann, U. F. O., Leal, S. & Finger, R. P.view all authors (2025). The Spectrum of Functional, Structural and Patient-Reported Outcomes in Intermediate Age-Related Macular Degeneration – A MACUSTAR Study Report. Ophthalmologica, 248(2), pp. 101-111. doi: 10.1159/000543231

Terheyden, J. H., Dunbar, H. M. P., Schmitz-Valckenberg, S. , Behning, C., Martinho, C., Luhmann, U. F. O., Saßmannshausen, M., Lüning, A., Miliu, A., Aires, I. D., Basile, P. G., Batuca, J., Schmid, M., Moll, K-P., Zakaria, N., Tufail, A., Binns, A., Crabb, D. P. ORCID: 0000-0001-8754-3902, Leal, S., Finger, R. P., Holz, F. G., Agostini, H., Aires, I. D., Altay, L., Atia, R., Bandello, F., Basile, P. G., Batuca, J., Behning, C., Belmouhand, M., Berger, M., Binns, A. ORCID: 0000-0001-8621-498X, Boon, C. J. F., Böttger, M., Brazier, J. E., Carapezzi, C., Carlton, J., Carneiro, A., Charil, A., Coimbra, R., Cosette, D., Cozzi, M., Crabb, D. P., Cunha-Vaz, J., Dahlke, C., Dunbar, H., Finger, R. P., Fletcher, E., Gutfleisch, M., Hartgers, F., Higgins, B., Hildebrandt, J., Höck, E., Hogg, R., Holz, F. G., Hoyng, C. B., Kilani, A., Krätzschmar, J., Kühlewein, L., Larsen, M., Leal, S., Lechanteur, Y. T. E., Lu, D., Luhmann, U. F. O., Lüning, A., Manivannan, N., Marques, I., Martinho, C., Miliu, A., Moll, K. P., Mulyukov, Z., Paques, M., Parodi, B., Parravano, M., Penas, S., Peters, T., Peto, T., Priglinger, S., Ramamirtham, R., Ribeiro, R., Rowen, D., Rubin, G. S., Sahel, J., Sánchez, C., Sander, O., Saßmannshausen, M., Schmid, M., Schmitz-Valckenberg, S., Siedlecki, J., Silva, R., Souied, E., Staurenghi, G., Tavares, J., Taylor, D. J. ORCID: 0000-0001-8261-5225, Terheyden, J. H., Tufail, A., Valmaggia, P., Varano, M., Wolf, A. & Zakaria, N.view all authors (2025). Validating candidate endpoints for intermediate age-related macular degeneration trials in a multi-centre setting—lessons from the MACUSTAR study. Eye, 39(6), pp. 1031-1039. doi: 10.1038/s41433-024-03568-2

Stuart, K. V., Biradar, M. I., Luben, R. N. , Dhaun, N., Wagner, S. K., Warwick, A. N., Sun, Z., Madjedi, K. M., Pasquale, L. R., Wiggs, J. L., Kang, J. H., Lentjes, M. A. H., Aschard, H., Kim, J., Foster, P. J., Khawaja, A. P., Aschard, H., Chia, M., Chua, S., Do, R., Foster, P., Kang, J., Kastner, A., Khawaja, A., Kim, J., Lentjes, M., Luben, R., Madjedi, K., Montesano, G. ORCID: 0000-0002-9148-2804, Pasquale, L., Stuart, K., Warwick, A., Wiggs, J., Allen, N., Aslam, T., Atan, D., Barman, S., Barrett, J., Bishop, P., Black, G., Braithwaite, T., Carare, R., Chakravarthy, U., Chan, M., Chua, S., Day, A., Desai, P., Dhillon, B., Dick, A., Doney, A., Egan, C., Ennis, S., Foster, P., Fruttiger, M., Garway-Heath, D. T., Gibson, J., Guggenheim, J., Hammond, C., Hardcastle, A., Harding, S., Hogg, R., Hysi, P., Keane, P., Khaw, P. T., Khawaja, A., Lascaratos, G., Littlejohns, T., Lotery, A., Luthert, P., MacGillivray, T., Mackie, S., McGuinness, B., McKay, G., McKibbin, M., Moore, T., Morgan, J., O'Sullivan, E., Oram, R., Owen, C., Patel, P., Paterson, E., Peto, T., Petzold, A., Pontikos, N., Rahi, J., Rudnicka, A., Sattar, N., Self, J., Sergouniotis, P., Sivaprasad, S., Steel, D., Stratton, I., Strouthidis, N., Sudlow, C., Sun, Z., Tapp, R., Thomas, D., Trucco, E., Tufail, A., Viswanathan, A., Vitart, V., Weedon, M., Williams, K., Williams, C., Woodside, J., Yates, M., Yip, J., Zheng, Y., Aung, T., Burdon, K., Chen, L., Cheng, C-Y., Craig, J., Cree, A., de Vries, V., Driessen, S., Fingert, J., Foster, P., Gharahkhani, P., Hammond, C., Hayward, C., Hewitt, A., Hysi, P., Jansonius, N., Jonansson, F., Jonas, J., Kass, M., Khawaja, A., Khor, C., Klaver, C., Koh, J., Lotery, A., MacGregor, S., Mackey, D., Mitchell, P., Pang, C., Pasquale, L., Pasutto, F., Pfeiffer, N., Polašek, O., Ramdas, W., Schuster, A., Segrè, A., Stefansson, E., Stefánsson, K., Thorleifsson, G., Thorsteinsdottir, U., van Duijn, C., Vergroesen, J., Viswanathan, A., Vitart, V., Vithana, E., Wiggs, J., Wilson, J., Wojciechowski, R., Wong, T. & Young, T.view all authors (2024). The Association of Urinary Sodium Excretion with Glaucoma and Related Traits in a Large United Kingdom Population. Ophthalmology Glaucoma, 7(5), pp. 499-511. doi: 10.1016/j.ogla.2024.04.010

Rowen, D., Carlton, J., Terheyden, J. H. , Finger, R. P., Wickramasekera, N., Brazier, J., Agostini, H., Altay, L., Atia, R., Bandello, F., Basile, P. G., Behning, C., Belmouhand, M., Berger, M., Binns, A. ORCID: 0000-0001-8621-498X, Boon, C. J. F., Böttger, M., Bouchet, C., Brazier, J. E., Butt, T., Carapezzi, C., Carlton, J., Carneiro, A., Charil, A., Coimbra, R., Cozzi, M., Crabb, D. P. ORCID: 0000-0001-8611-1155, Cunha-Vaz, J., Dahlke, C., de Sisternes, L., Dunbar, H., Finger, R. P., Fletcher, E., Floyd, H., Francisco, C., Gutfleisch, M., Hogg, R., Holz, F. G., Hoyng, C. B., Kilani, A., Krätzschmar, J., Kühlewein, L., Larsen, M., Leal, S., Lechanteur, Y. T. E., Luhmann, U. F. O., Lüning, A., Marques, I., Martinho, C., Montesano, G. ORCID: 0000-0002-9148-2804, Mulyukov, Z., Paques, M., Parodi, B., Parravano, M., Penas, S., Peters, T., Peto, T., Pfau, M., Poor, S., Priglinger, S., Rowen, D., Rubin, G. S., Sahel, J., Sanches Fernandes, D., Sánchez, C., Sander, O., Saßmannshausen, M., Schmid, M., Schmitz-Valckenberg, S., Schrinner-Fenske, H., Siedlecki, J., Silva, R., Skelly, A., Souied, E., Staurenghi, G., Stöhr, L., Tavares, D., Tavares, J., Taylor, D. J. ORCID: 0000-0001-8261-5225, Terheyden, J. H., Thiele, S., Tufail, A., Varano, M., Vieweg, L., Werner, J., Wintergerst, L., Wolf, A. & Zakaria, N.view all authors (2024). Development and Valuation of a Preference-Weighted Measure in Age-Related Macular Degeneration From the Vision Impairment in Low Luminance Questionnaire—A MACUSTAR Report. Value in Health, 27(5), pp. 642-654. doi: 10.1016/j.jval.2024.02.001

von der Emde, L., Mallwitz, M., Vaisband, M. , Hasenauer, J., Saßmannshausen, M., Terheyden, J. H., Agostini, H., Altay, L., Atia, R., Bandello, F., Basile, P. G., Batuca, J., Behning, C., Belmouhand, M., Berger, M., Binns, A. M. ORCID: 0000-0001-8621-498X, Boon, C. J. F., Böttger, M., Bouchet, C., Brazier, J E., Butt, T., Carapezzi, C., Carlton, J., Carneiro, A., Charil, A., Coimbra, R., Cozzi, M., Crabb, D. P. ORCID: 0000-0001-8611-1155, Cunha-Vaz, J., Dahlke, C., de Sisternes, L., Dunbar, H., Finger, R. P., Fletcher, E, Floyd, H., Francisco, C., Gutfleisch, M., Hinz, S., Hogg, R., Holz, F. G., Hoyng, C. B., Kilani, A., Krätzschmar, J., Kühlewein, L., Larsen, M., Leal, S., Lechanteur, Y. T. E., Luhmann, U. F. O., Lüning, A., Marques, I., Martinho, C., Montesano, G. ORCID: 0000-0002-9148-2804, Mulyukov, Z., Paques, M., Parodi, B., Parravano, M., Penas, S., Peters, T., Peto, T., Pfau, M., Poor, S., Priglinger, S., Rowen, D., Rubin, G. S., Sahel, J., Sánchez, C., Sander, O., Schmid, M., Schmitz-Valckenberg, S., Siedlecki, J., Silva, R., Skelly, A., Souied, E., Staurenghi, G., Stöhr, L., Taylor, D. J., Terheyden, J. H., Thiele, S., Tufail, A., Varano, M., Vieweg, L., Wintergerst, L., Wolf, A., Zakaria, N., Sloan, K. R., Schmitz-Valckenberg, S., Finger, R. P., Holz, F. G. & Ach, T.view all authors (2023). Retest variability and patient reliability indices of quantitative fundus autofluorescence in age-related macular degeneration: a MACUSTAR study report. Scientific Reports, 13(1), article number 17417. doi: 10.1038/s41598-023-43417-y

Learoyd, A. E., Tufail, A., Bunce, C. , Keane, P. A., Kernohan, A., Robinson, E., Jaber, A., Sadiq, S., Harper, R. A., Lawrenson, J. ORCID: 0000-0002-2031-6390, Vale, L., Waterman, H., Douiri, A., Balaskas, K. & FENETRE study groupview all authors (2021). FENETRE study: quality-assured follow-up of quiescent neovascular age-related macular degeneration by non-medical practitioners: study protocol and statistical analysis plan for a randomised controlled trial.. BMJ Open, 11(5), article number e049411. doi: 10.1136/bmjopen-2021-049411

Terheyden, J. H., Behning, C., Lüning, A. , Wintergerst, L., Basile, P., Tavares, D., Melício, B., Leal, S., Weissgerber, G., Luhmann, U. F. O., Crabb, D. P. ORCID: 0000-0001-8754-3902, Tufail, A., Hoyng, C., Berger, M., Schmid, M., Silva, R., Martinho, C., Cunha-Vaz, J., Holz, F. G., Finger, R. P. & MACUSTAR consortiumview all authors (2021). Challenges, facilitators and barriers to screening study participants in early disease stages-experience from the MACUSTAR study. BMC Medical Research Methodology, 21(1), article number 54. doi: 10.1186/s12874-021-01243-8

Terheyden, J. H., Schmitz-Valckenberg, S., Crabb, D. P. ORCID: 0000-0001-8754-3902 , Dunbar, H., Luhmann, U. F. O., Behning, C., Schmid, M., Pires, I., Cunha-Vaz, J., Tufail, A., Weissgerber, G., Leal, S., Holz, F. G. & Finger, R. P.view all authors (2020). Use of composite endpoints in early and intermediate age-related macular degeneration clinical trials - state-of-the-art and future directions. Ophthalmologica, 244(5), pp. 387-395. doi: 10.1159/000513591

Terheyden, J. H., Holz, F. G., Schmitz-Valckenberg, S. , Lüning, A., Schmid, M., Rubin, G. S., Dunbar, H., Tufail, A., Crabb, D. P. ORCID: 0000-0001-8754-3902, Binns, A. M., Sánchez, C. I., Hoyng, C., Margaron, P., Zakaria, N., Durbin, M., Luhmann, U., Zamiri, P., Cunha-Vaz, J., Martinho, C., Leal, S., Finger, R. P. & MACUSTAR consortiumview all authors (2020). Clinical study protocol for a low-interventional study in intermediate age-related macular degeneration developing novel clinical endpoints for interventional clinical trials with a regulatory and patient access intention-MACUSTAR.. Trials, 21(1), article number 659. doi: 10.1186/s13063-020-04595-6

Montesano, G., Ometto, G., Higgins, B. E. , Iester, C., Balaskas, K., Tufail, A., Chakravarthy, U., Hogg, R. E. & Crabb, D. P. ORCID: 0000-0001-8754-3902view all authors (2020). Structure-Function Analysis in Macular Drusen With Mesopic and Scotopic Microperimetry. Translational Vision Science and Technology, 9(13), article number 43. doi: 10.1167/tvst.9.13.43

Pozarickij, A., Williams, C., Hysi, P. G. , Guggenheim, J. A., Aslam, T., Barman, S. A., Barrett, J. H., Bishop, P., Blows, P., Bunce, C., Carare, R. O., Chakravarthy, U., Chan, M., Chua, S. Y. L., Crabb, D. P. ORCID: 0000-0001-8754-3902, Cumberland, P. M., Day, A., Desai, P., Dhillon, B., Dick, A. D., Egan, C., Ennis, S., Foster, P., Fruttiger, M., Gallacher, J. E. J., Garway-Heath, D. F., Gibson, J., Gore, D., Hammond, C. J., Hardcastle, A., Harding, S. P., Hogg, R. E., Keane, P. A., Khaw, S. P. T., Khawaja, A. P., Lascaratos, G., Lotery, A. J., Mac Gillivray, T., Mackie, S., Martin, K., McGaughey, M., McGuinness, B., McKay, G. J., McKibbin, M., Mitry, D., Moore, T., Morgan, J. E., Muthy, Z. A., O’Sullivan, E., Owen, C. G., Patel, P., Paterson, E., Peto, T., Petzold, A., Rahi, J. S., Rudnikca, A. R., Self, J., Sivaprasad, S., Steel, D., Stratton, I., Strouthidis, N., Sudlow, C., Thomas, D., Trucco, E., Tufail, A., Vitart, V., Vernon, S. A., Viswanathan, A. C., Williams, K., Woodside, J. V., Yates, M. M., Yip, J. & Zheng, Y.view all authors (2019). Quantile regression analysis reveals widespread evidence for gene-environment or gene-gene interactions in myopia development. Communications Biology, 2(1), article number 167. doi: 10.1038/s42003-019-0387-5

Chua, S. Y. L., Dhillon, B., Aslam, T. , Balaskas, K., Yang, Q., Keane, P. A., Tufail, A., Reisman, C., Foster, P. J., Patel, P. J., Bishop, P., Barman, S. A., Barrett, J. H., Blows, P., Bunce, C., Carare, R. O., Chakravarthy, U., Chan, M., Crabb, D. P. ORCID: 0000-0001-8754-3902, Cumberland, P. M., Day, A., Desai, P., Sudlow, C., Dick, A. D., Egan, C., Ennis, S., Fruttiger, M., Gallacher, J. E. J., Garway-Heath, D. F., Gibson, J., Gore, D., Guggenheim, J. A., Hammond, C. J., Hardcastle, A., Harding, S. P., Hogg, R. E., Hysi, P., Khaw, Sir P. T., Khawaja, A.P., Lascaratos, G., Lotery, A. J., Macgillivray, T., Mackie, S., Martin, K., Mcgaughey, M., Mcguinness, B., Mckay, G. J., Mckibbin, M., Mitry, D., Moore, T., Morgan, J. E., Muthy, Z. A., O'Sullivan, E., Owen, C. G., Paterson, E., Peto, T., Petzold, A., Rahi, J. S., Rudnicka, A. R., Self, J., Sivaprasad, S., Steel, D., Stratton, I., Strouthidis, N., Thaung, C., Thomas, D., Trucco, E., Vitart, V., Vernon, S. A., Viswanathan, A. C., Williams, C., Williams, K., Woodside, J. V., Yates, M. M., Yip, J., Zheng, Y. & Tapp, R.view all authors (2019). Associations with photoreceptor thickness measures in the UK Biobank. Scientific Reports, 9(1), article number 19440. doi: 10.1038/s41598-019-55484-1

Denniston, A. K., Lee, A. Y., Lee, C. S. , Crabb, D. P. ORCID: 0000-0001-8754-3902, Bailey, C., Lip, P-L., Taylor, P., Pikoula, M., Cook, E., Akerele, T., Antcliff, R., Brand, C., Chakravarthy, U., Chavan, R., Dhingra, N., Downey, L., Eleftheriadis, H., Ghanchi, F., Khan, R., Kumar, V., Lobo, A., Lotery, A., Menon, G., Mukherjee, R., Palmer, H., Patra, S., Paul, B., Sim, D. A., Talks, J. S., Wilkinson, E., Tufail, A. & Egan, C. A.view all authors (2019). United Kingdom Diabetic Retinopathy Electronic Medical Record (UK DR EMR) Users Group: report 4, real-world data on the impact of deprivation on the presentation of diabetic eye disease at hospital services.. British Journal of Ophthalmology, 103(6), pp. 837-843. doi: 10.1136/bjophthalmol-2018-312568

Finger, R. P., Schmitz-Valckenberg, S., Schmidt, M. , Rubin, G. S., Dunbar, H., Tufail, A., Crabb, D. P. ORCID: 0000-0001-8754-3902, Binns, A. M. ORCID: 0000-0001-8621-498X, Sánchez, C. I., Margaron, P., Normand, G., Durbin, M. K., Luhmann, U. F. O., Zamiri, P., Cunha-Vaz, J., Asmus, F. & Holz, F. G.view all authors (2018). MACUSTAR: Development and Clinical Validation of Functional, Structural, and Patient-Reported Endpoints in Intermediate Age-Related Macular Degeneration. Ophthalmologica, 241(2), pp. 61-72. doi: 10.1159/000491402

Denniston, A. K., Chakravarthy, U., Zhu, H. , Lee, A. Y., Crabb, D. P. ORCID: 0000-0001-8754-3902, Tufail, A., Bailey, C., Akerele, T., Al-Husainy, S., Brand, C., Downey, L., Fitt, A., Khan, R., Kumar, V., Lobo, A., Mahmood, S., Mandal, K., Mckibbin, M., Menon, G., Natha, S., Ong, J. M., Tsaloumas, M. D., Varma, A., Wilkinson, E., Johnston, R. L. & Egan, C. A.view all authors (2017). The UK Diabetic Retinopathy Electronic Medical Record (UK DR EMR) Users Group, Report 2: real-world data for the impact of cataract surgery on diabetic macular oedema. British Journal of Ophthalmology, 101(12), pp. 1673-1678. doi: 10.1136/bjophthalmol-2016-309838

Lee, C. S., Lee, A. Y., Baughman, D. , Sim, D., Akelere, T., Brand, C., Crabb, D. P. ORCID: 0000-0001-8754-3902, Denniston, A. K., Downey, L., Fitt, A., Khan, R., Mahmood, S., Mandal, K., Mckibbin, M., Menon, G., Lobo, A., Kumar, B. V., Natha, S., Varma, A., Wilkinson, E., Mitry, D., Bailey, C., Chakravarthy, U., Tufail, A. & Egan, C.view all authors (2017). The United Kingdom Diabetic Retinopathy Electronic Medical Record Users Group: Report 3: Baseline Retinopathy and Clinical Features Predict Progression of Diabetic Retinopathy. American Journal of Ophthalmology, 180, pp. 64-71. doi: 10.1016/j.ajo.2017.05.020

Egan, C., Zhu, H., Lee, A. , Sim, D., Mitry, D., Bailey, C., Johnston, R., Chakravarthy, U., Denniston, A., Tufail, A., Khan, R., Mahmood, S., Menon, G., Akerele, T., Downey, L., McKibbin, M., Varma, A., Lobo, A., Wilkinson, E., Fitt, A., Brand, C., Tsaloumas, M., Mandal, K., Kumar, V., Natha, S. & Crabb, D. P. ORCID: 0000-0001-8754-3902view all authors (2017). The United Kingdom Diabetic Retinopathy Electronic Medical Record Users Group, Report 1: baseline characteristics and visual acuity outcomes in eyes treated with intravitreal injections of ranibizumab for diabetic macular oedema. British Journal of Ophthalmology, 101(1), pp. 75-80. doi: 10.1136/bjophthalmol-2016-309313

Powner, M. B., Sim, D. A., Zhu, M. , Nobre-Cardoso, J., Jones, R., Syed, A., Chang, A. A., Keane, P. A., Tufail, A., Egan, C. A. & Fruttiger, M.view all authors (2016). Evaluation of Nonperfused Retinal Vessels in Ischemic Retinopathy. Investigative Ophthalmology and Visual Science, 57(11), pp. 5031-5037. doi: 10.1167/iovs.16-20007

Sim, D. A., Keane, P. A., Zarranz-Ventura, J. , Fung, S. S. M., Powner, M. B., Platteau, E., Bunce, C. V., Fruttiger, M., Patel, P. J., Tufail, A. & Egan, C. A.view all authors (2013). The effects of macular ischemia on visual acuity in diabetic retinopathy. Investigative Ophthalmology & Visual Science, 54(3), pp. 2353-2360. doi: 10.1167/iovs.12-11103

Conference or Workshop Item

Dunbar, H. M. P., Sassmannshausen, M., Behning, C. , Thiele, S., Binns, A. M. ORCID: 0000-0001-8621-498X, Higgins, B. E. ORCID: 0000-0002-4530-6156, Terheyden, J. H., Tufail, A., Leal, S., Zakaria, N., Holz, F. G., Schmid, M., Finger, R. P., Crabb, D. P. ORCID: 0000-0001-8611-1155, Schmitz-Valckenberg, S. & Luhmann, U. F. O.view all authors (2022). Comparison of visual function in structurally defined sub-phenotypes of intermediate AMD: A MACUSTAR study report. In: Investigative Ophthalmology & Visual Science. ARVO Annual Meeting 2022, 1-4 May 2022, Denver, USA.