FCNet: A Convolutional Neural Network for Calculating Functional Connectivity from functional MRI

Riaz, A., Asad, M., Al-Arid, S. M. M. R., Alonso, E., Dima, D., Corr, P. J. & Slabaugh, G.G. (2017). FCNet: A Convolutional Neural Network for Calculating Functional Connectivity from functional MRI. Paper presented at the 1st International Workshop on Connectomics in NeuroImaging (CNI), 14 Sep 2017, Quebec City, Canada.

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Investigation of functional brain connectivity patterns using functional MRI has received significant interest in the neuroimaging domain. Brain functional connectivity alterations have widely been exploited for diagnosis and prediction of various brain disorders. Over the last several years, the research community has made tremendous advancements in constructing brain functional connectivity from timeseries functional MRI signals using computational methods. However, even modern machine learning techniques rely on conventional correlation and distance measures as a basic step towards the calculation of the functional connectivity. Such measures might not be able to capture the latent characteristics of raw time-series signals. To overcome this shortcoming, we propose a novel convolutional neural network based model, FCNet, that extracts functional connectivity directly from raw fMRI time-series signals. The FCNet consists of a convolutional neural network that extracts features from time-series signals and a fully connected network that computes the similarity between the extracted features in a Siamese architecture. The functional connectivity computed using FCNet is combined with phenotypic information and used to classify individuals as healthy controls or neurological disorder subjects. Experimental results on the publicly available ADHD-200 dataset demonstrate that this innovative framework can improve classification accuracy, which indicates that the features learnt from FCNet have superior discriminative power.

Item Type: Conference or Workshop Item (Paper)
Additional Information: The final publication will be available at Springer via http://www.springer.com/br/computer-science/lncs.
Uncontrolled Keywords: Functional Connectivity, CNN, fMRI, Deep Learning
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: School of Informatics > Department of Computing
School of Social Sciences > Department of Psychology
URI: http://openaccess.city.ac.uk/id/eprint/18045

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