City Research Online

Analysis of the Interactions of Migrating Macrophages

Solis-Lemus, J. A., Stramer, B., Slabaugh, G.G. and Reyes-Aldasoro, C. C. ORCID: 0000-0002-9466-2018 (2018). Analysis of the Interactions of Migrating Macrophages. Communications in Computer and Information Science, 2018, pp. 262-273. doi: 10.1007/978-3-319-95921-4_25

Abstract

Understanding the migrating patterns of cells in the immune system is of great importance; especially the changes of direction and its cause. For macrophages and other immune cells, excessive migration could be related to autoimmune diseases and cancer. In this work, an algorithm to analyse the change in direction of cells before and after they interact with another cell is proposed. The main objective is to provide insights into the notion that interactions between cell structures appear to anticipate migration. Such interactions are determined when the cells overlap and form clumps of two or more cells. The algorithm integrates a segmentation technique capable of detecting overlapping cells and a tracking framework into a tool for the analysis of the trajectories of cells before and after they overlap. The preliminary results show promise into the analysis and the hypothesis proposed, and it lays the ground work for further developments.

Publication Type: Article
Additional Information: The final authenticated version is to be available online at https://doi.org/10.1007/978-3-319-95921-4_25
Publisher Keywords: Segmentation, Cell Tracking, Track analysis, Macrophages
Departments: School of Mathematics, Computer Science & Engineering > Engineering
School of Mathematics, Computer Science & Engineering > Engineering > Electrical & Electronic Engineering
URI: http://openaccess.city.ac.uk/id/eprint/19562
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